Kimberly-Marie M Gorion
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Explore the profile of Kimberly-Marie M Gorion including associated specialties, affiliations and a list of published articles.
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12
Citations
125
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Recent Articles
1.
Paterno G, Moore B, Bell B, Gorion K, Ran Y, Prokop S, et al.
Antibodies (Basel)
. 2024 Aug;
13(3).
PMID: 39189239
Amyloid-β (Aβ) deposition throughout the neuroaxis is a classical hallmark of several neurodegenerative diseases, most notably Alzheimer's disease (AD). Aβ peptides of varied length and diverse structural conformations are deposited...
2.
Lloyd G, Quintin S, Sorrentino Z, Gorion K, Bell B, Long B, et al.
Acta Neuropathol Commun
. 2024 Jun;
12(1):91.
PMID: 38858742
Synucleinopathies are a group of neurodegenerative disorders characterized by the presence of misfolded α-Synuclein (αSyn) in the brain. These conditions manifest with diverse clinical and pathophysiological characteristics. This disease diversity...
3.
Lloyd G, Dhillon J, Gorion K, Riffe C, Fromholt S, Xia Y, et al.
Mol Neurodegener
. 2024 Feb;
19(1):17.
PMID: 38365847
No abstract available.
4.
Paterno G, Torrellas J, Bell B, Gorion K, Quintin S, Hery G, et al.
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37761979
Tau proteins within the adult central nervous system (CNS) are found to be abnormally aggregated into heterogeneous filaments in neurodegenerative diseases, termed tauopathies. These tau inclusions are pathological hallmarks of...
5.
Lloyd G, Long B, Quintin S, Sorrentino Z, Gorion K, Bell B, et al.
Acta Neuropathol Commun
. 2023 Jul;
11(1):119.
PMID: 37482615
Post-translational modifications to the carboxyl (C) terminus domain of α-synuclein can play an important role in promoting the pathologic aggregation of α-synuclein. Various cleavages that diminish this highly charged, proline-rich...
6.
Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology
Paterno G, Bell B, Gorion K, Prokop S, Giasson B
Acta Neuropathol Commun
. 2022 Jun;
10(1):94.
PMID: 35765058
Tau is a predominantly neuronal, soluble and natively unfolded protein that can bind and stabilize microtubules in the central nervous system. Tau has been extensively studied over several decades, especially...
7.
Xia Y, Prokop S, Bell B, Gorion K, Croft C, Nasif L, et al.
Commun Biol
. 2022 May;
5(1):446.
PMID: 35550593
Pathological tau inclusions are neuropathologic hallmarks of many neurodegenerative diseases. We generated and characterized a transgenic mouse model expressing pathogenic human tau with S320F and P301S aggregating mutations (SPAM) at...
8.
Lloyd G, Sorrentino Z, Quintin S, Gorion K, Bell B, Paterno G, et al.
Acta Neuropathol
. 2022 Apr;
143(6):663-685.
PMID: 35488930
α-synuclein (αSyn) is an intrinsically disordered protein which can undergo structural transformations, resulting in the formation of stable, insoluble fibrils. αSyn amyloid-type nucleation can be induced by misfolded 'seeds' serving...
9.
Lloyd G, Dhillon J, Gorion K, Riffe C, Fromholt S, Xia Y, et al.
Mol Neurodegener
. 2021 Sep;
16(1):63.
PMID: 34503546
Background: The misfolding of host-encoded proteins into pathological prion conformations is a defining characteristic of many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Lewy body dementia. A current area...
10.
Xia Y, Prokop S, Gorion K, Kim J, Sorrentino Z, Bell B, et al.
Acta Neuropathol Commun
. 2020 Jun;
8(1):88.
PMID: 32571418
Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer's disease (AD). In early stages of disease, tau becomes hyperphosphorylated and mislocalized, which can contribute...