David R Borchelt
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Explore the profile of David R Borchelt including associated specialties, affiliations and a list of published articles.
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151
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6562
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Recent Articles
1.
Levites Y, Dammer E, Ran Y, Tsering W, Duong D, Abreha M, et al.
Cell Rep Med
. 2024 Aug;
5(8):101669.
PMID: 39127040
Alzheimer's disease (AD) is a complex neurodegenerative disorder that develops over decades. AD brain proteomics reveals vast alterations in protein levels and numerous altered biologic pathways. Here, we compare AD...
2.
Smith E, McKenna R, Mietzsch M, Borchelt D, Prokop S, Chakrabarty P
bioRxiv
. 2024 Apr;
PMID: 38659970
Acetylation of key Lysine residues characterizes aggregates of the microtubule-associated protein tau constituting the neuropathological hallmark of many neurodegenerative diseases, such as Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP)....
3.
Lloyd G, Dhillon J, Gorion K, Riffe C, Fromholt S, Xia Y, et al.
Mol Neurodegener
. 2024 Feb;
19(1):17.
PMID: 38365847
No abstract available.
4.
Levites Y, Dammer E, Ran Y, Tsering W, Duong D, Abreha M, et al.
bioRxiv
. 2023 Dec;
PMID: 38076912
We report a highly significant correlation in brain proteome changes between Alzheimers disease (AD) and CRND8 APP695NL/F transgenic mice. However, integrating protein changes observed in the CRND8 mice with co-expression...
5.
Smith E, Vo Q, Giasson B, Borchelt D, Prokop S, Chakrabarty P
Acta Neuropathol Commun
. 2023 Oct;
11(1):172.
PMID: 37891635
Distinctive post-translational modifications (PTM) characterize tau inclusions found in tauopathy patients. Using detergent-insoluble tau isolated from Alzheimer's disease (AD-tau) or Progressive Supranuclear Palsy (PSP-tau) patients, we provide insights into whether...
6.
Ayers J, Xu G, Lu Q, Dillon K, Fromholt S, Borchelt D
Viruses
. 2023 Sep;
15(9).
PMID: 37766226
Mutations in superoxide dismutase 1 (SOD1) that are associated with amyotrophic lateral sclerosis (ALS) cause its misfolding and aggregation. Prior studies have demonstrated that the misfolded conformation of ALS-SOD1 can...
7.
Williams T, Bathe T, Vo Q, Sacilotto P, McFarland K, Ruiz A, et al.
Acta Neuropathol Commun
. 2023 Jun;
11(1):99.
PMID: 37337279
Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer's disease and contributes to metabolic and neuropathological abnormalities during brain aging. To provide insights into whether APOE4 genotype is...
8.
Xu G, Fromholt S, Borchelt D
Biomolecules
. 2022 Jul;
12(7).
PMID: 35883442
The amyloid pathology characteristic of Alzheimer's disease (AD) can be broadly classified as either fibrillary amyloid or diffuse amyloid. Fibrillary amyloid is found in cored-neuritic deposits, fibrillar deposits, and vascular...
9.
Xia Y, Prokop S, Bell B, Gorion K, Croft C, Nasif L, et al.
Commun Biol
. 2022 May;
5(1):446.
PMID: 35550593
Pathological tau inclusions are neuropathologic hallmarks of many neurodegenerative diseases. We generated and characterized a transgenic mouse model expressing pathogenic human tau with S320F and P301S aggregating mutations (SPAM) at...
10.
Moore B, Levites Y, Xu G, Hampton H, Adamo M, Croft C, et al.
Free Neuropathol
. 2022 May;
3(9).
PMID: 35494163
Background: Seeding of pathology related to Alzheimer's disease (AD) and Lewy body disease (LBD) by tissue homogenates or purified protein aggregates in various model systems has revealed prion-like properties of...