Kimberlee P Giffen
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Explore the profile of Kimberlee P Giffen including associated specialties, affiliations and a list of published articles.
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10
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174
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Recent Articles
1.
Giffen K, Liu H, Yamane K, Li Y, Chen L, Kramer K, et al.
Front Neurol
. 2024 Nov;
15:1437558.
PMID: 39484049
Introduction: Hair cells (HCs) are the sensory receptors of the auditory and vestibular systems in the inner ears of vertebrates that selectively transduce mechanical stimuli into electrical activity. Although all...
2.
Giffen K, Liu H, Yamane K, Li Y, Chen L, Kramer K, et al.
bioRxiv
. 2024 Jun;
PMID: 38826418
Hair cells (HCs) are the sensory receptors of the auditory and vestibular systems in the inner ears of vertebrates that selectively transduce mechanical stimuli into electrical activity. Although all HCs...
3.
Martin A, Giffen K
Med Teach
. 2024 Mar;
46(10):1291-1295.
PMID: 38478983
Simulation-based education (SBE) is common in healthcare education and is increasingly being incorporated in preclinical curriculum. Preclinical students typically have had little exposure to the clinical setting (i.e. hospital patient...
4.
Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells
Liu H, Giffen K, Chen L, Henderson H, Cao T, Kozeny G, et al.
Cell Rep
. 2022 Apr;
39(2):110665.
PMID: 35417713
Age-related hearing loss (ARHL) negatively impacts quality of life in the elderly population. The prevalent cause of ARHL is loss of mechanosensitive cochlear hair cells (HCs). The molecular and cellular...
5.
Giffen K, Li Y, Liu H, Zhao X, Zhang C, Shen R, et al.
Sci Adv
. 2022 Apr;
8(14):eabk0942.
PMID: 35394837
Lysosomes contribute to cellular homeostasis via processes including macromolecule degradation, nutrient sensing, and autophagy. Defective proteins related to lysosomal macromolecule catabolism are known to cause a range of lysosomal storage...
6.
Liu H, Giffen K, Grati M, Morrill S, Li Y, Liu X, et al.
J Cell Sci
. 2021 Mar;
134(7).
PMID: 33674448
Hearing loss affects ∼10% of adults worldwide. Most sensorineural hearing loss is caused by the progressive loss of mechanosensitive hair cells (HCs) in the cochlea. The molecular mechanisms underlying HC...
7.
Giffen K, Liu H, Kramer K, He D
Front Neurosci
. 2019 Nov;
13:1117.
PMID: 31680844
Non-mammalian vertebrates, including zebrafish, retain the ability to regenerate hair cells (HCs) due to unknown molecular mechanisms that regulate proliferation and conversion of non-sensory supporting cells (nsSCs) to HCs. This...
8.
Liu H, Chen L, Giffen K, Stringham S, Li Y, Judge P, et al.
Front Mol Neurosci
. 2018 Oct;
11:356.
PMID: 30327589
The mammalian auditory sensory epithelium, the organ of Corti, is composed of hair cells and supporting cells. Hair cells contain specializations in the apical, basolateral and synaptic membranes. These specializations...
9.
Li Y, Liu H, Giffen K, Chen L, Beisel K, He D
Sci Data
. 2018 Oct;
5:180199.
PMID: 30277483
Inner hair cells (IHCs) and outer hair cells (OHCs) are the two anatomically and functionally distinct types of mechanosensitive receptor cells in the mammalian cochlea. The molecular mechanisms defining their...
10.
Barta C, Liu H, Chen L, Giffen K, Li Y, Kramer K, et al.
Sci Data
. 2018 Feb;
5:180005.
PMID: 29406519
Although hair cells are the sensory receptors of the auditory and vestibular systems in the ears of all vertebrates, hair cell properties are different between non-mammalian vertebrates and mammals. To...