Kim W McIntyre
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Explore the profile of Kim W McIntyre including associated specialties, affiliations and a list of published articles.
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66
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1106
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Recent Articles
1.
Gilmore J, Xiao H, Murali Dhar T, Yang M, Xiao Z, Yang X, et al.
J Med Chem
. 2021 Jan;
64(3):1454-1480.
PMID: 33492963
Sphingosine-1-phosphate (S1P) binds to a family of sphingosine-1-phosphate G-protein-coupled receptors (S1P). The interaction of S1P with these S1P receptors has a fundamental role in many physiological processes in the vascular...
2.
Liu C, Lin J, Langevine C, Smith D, Li J, Tokarski J, et al.
J Med Chem
. 2020 Dec;
64(1):677-694.
PMID: 33370104
A search for structurally diversified Tyk2 JH2 ligands from (BMS-986165), a pyridazine carboxamide-derived Tyk2 JH2 ligand as a clinical Tyk2 inhibitor currently in late development for the treatment of psoriasis,...
3.
Srivastava A, Ko S, Watterson S, Pattoli M, Skala S, Cheng L, et al.
ACS Med Chem Lett
. 2020 Nov;
11(11):2195-2203.
PMID: 33214829
Bruton's tyrosine kinase (BTK) has been shown to play a key role in the pathogenesis of autoimmunity. Therefore, the inhibition of the kinase activity of BTK with a small molecule...
4.
Xiao Z, Yang M, Murali Dhar T, Xiao H, Gilmore J, Marcoux D, et al.
ACS Med Chem Lett
. 2020 Sep;
11(9):1766-1772.
PMID: 32944145
Efforts aimed at increasing the in vivo potency and reducing the elimination half-life of and led to the identification of aryl ether and thioether-derived bicyclic S1P differentiated modulators -. The...
5.
Marcoux D, Duan J, Shi Q, Cherney R, Srivastava A, Cornelius L, et al.
J Med Chem
. 2019 Oct;
62(21):9931-9946.
PMID: 31638797
RORγt is an important nuclear receptor that regulates the production of several pro-inflammatory cytokines such as IL-17 and IL-22. As a result, RORγt has been identified as a potential target...
6.
Burke J, Cheng L, Gillooly K, Strnad J, Zupa-Fernandez A, Catlett I, et al.
Sci Transl Med
. 2019 Jul;
11(502).
PMID: 31341059
TYK2 is a nonreceptor tyrosine kinase involved in adaptive and innate immune responses. A deactivating coding variant has previously been shown to prevent receptor-stimulated activation of this kinase and provides...
7.
Wrobleski S, Moslin R, Lin S, Zhang Y, Spergel S, Kempson J, et al.
J Med Chem
. 2019 Jul;
62(20):8973-8995.
PMID: 31318208
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally target the catalytically active site of...
8.
Moslin R, Zhang Y, Wrobleski S, Lin S, Mertzman M, Spergel S, et al.
J Med Chem
. 2019 Jul;
62(20):8953-8972.
PMID: 31314518
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1...
9.
Watterson S, Liu Q, Bertrand M, Batt D, Li L, Pattoli M, et al.
J Med Chem
. 2019 Mar;
62(7):3228-3250.
PMID: 30893553
Bruton's tyrosine kinase (BTK), a non-receptor tyrosine kinase, is a member of the Tec family of kinases and is essential for B cell receptor (BCR) mediated signaling. BTK also plays...
10.
Liu C, Lin J, Moslin R, Tokarski J, Muckelbauer J, Chang C, et al.
ACS Med Chem Lett
. 2019 Mar;
10(3):383-388.
PMID: 30891145
In sharp contrast to a previously reported series of 6-anilino imidazopyridazine based Tyk2 JH2 ligands, 6-((2-oxo-1-substituted-1,2-dihydropyridin-3-yl)amino)imidazo[1,2-]pyridazine analogs were found to display dramatically improved metabolic stability. The N1-substituent on 2-oxo-1,2-dihydropyridine ring...