Kim J Krishnan
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Explore the profile of Kim J Krishnan including associated specialties, affiliations and a list of published articles.
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25
Citations
1585
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Recent Articles
1.
Campbell G, Krishnan K, Deschauer M, Taylor R, Turnbull D
Hum Mol Genet
. 2014 Apr;
23(17):4612-20.
PMID: 24740879
Large-scale mitochondrial DNA (mtDNA) deletions are an important cause of mitochondrial disease, while somatic mtDNA deletions cause focal respiratory chain deficiency associated with ageing and neurodegenerative disorders. As mtDNA deletions...
2.
Alston C, Schaefer A, Raman P, Solaroli N, Krishnan K, Blakely E, et al.
Neurology
. 2013 Nov;
81(23):2051-3.
PMID: 24198295
Mutations in nuclear genes involved in the maintenance of mitochondrial DNA (mtDNA) are associated with an extensive spectrum of clinical phenotypes, manifesting as either mtDNA depletion syndromes or multiple mtDNA...
3.
Campbell G, Kraytsberg Y, Krishnan K, Ohno N, Ziabreva I, Reeve A, et al.
Acta Neuropathol
. 2012 Jun;
124(2):209-20.
PMID: 22688405
Mitochondrial DNA deletions (∆-mtDNA) have been implicated in the pathogenesis of Alzheimer's disease (AD), multiple sclerosis (MS) and Parkinson's disease (PD), as well as ageing. Clonal expansion of ∆-mtDNA is...
4.
Reeve A, Park T, Jaros E, Campbell G, Lax N, Hepplewhite P, et al.
Arch Neurol
. 2012 Mar;
69(3):385-93.
PMID: 22410447
Objective: To explore the relationship between α-synuclein pathology and mitochondrial respiratory chain protein levels within single substantia nigra neurons. Design: We examined α-synuclein and mitochondrial protein expression in substantia nigra...
5.
Krishnan K, Ratnaike T, de Gruyter H, Jaros E, Turnbull D
Neurobiol Aging
. 2011 Sep;
33(9):2210-4.
PMID: 21925769
Alzheimer's disease (AD) is the most common form of dementia, increasing in prevalence with age. Most patients who develop AD have an unknown cause, but characteristic neuropathological features include the...
6.
Campbell G, Ziabreva I, Reeve A, Krishnan K, Reynolds R, Howell O, et al.
Ann Neurol
. 2011 Mar;
69(3):481-92.
PMID: 21446022
Objective: Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely, mitochondria harbor their...
7.
Guo X, Popadin K, Markuzon N, Orlov Y, Kraytsberg Y, Krishnan K, et al.
Trends Genet
. 2010 Jul;
26(8):340-3.
PMID: 20591530
Perfect direct repeats and, in particular, the prominent 13 bp repeat, are thought to cause mitochondrial DNA (mtDNA) deletions, which have been associated with the aging process. Accordingly, individuals lacking...
8.
Krishnan K, Turnbull D
Essays Biochem
. 2010 Jun;
47:139-51.
PMID: 20533905
From their very beginning to the present day, mitochondria have evolved to become a crucial organelle within the cell. The mitochondrial genome encodes only 37 genes, but its compact structure...
9.
Elson J, Apabhai S, Gorman G, Whittaker R, Krishnan K
Genet Med
. 2010 May;
12(5):313-4.
PMID: 20474085
Purpose: Single large-scale mitochondrial DNA deletions account for a quarter of mitochondrial disease cases and occur sporadically with unknown risk factors. Mitochondrial DNA deletions accumulate with age in many tissues....
10.
Krishnan K, Blackwood J, Reeve A, Turnbull D, Taylor R
Methods Mol Biol
. 2010 Mar;
628:227-57.
PMID: 20238085
The ability to detect mitochondrial DNA (mtDNA) variation within human cells is important not only to identify mutations causing mtDNA disease, but also as mtDNA mutations are being increasingly described...