Kiara N Berrios
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Explore the profile of Kiara N Berrios including associated specialties, affiliations and a list of published articles.
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10
Citations
203
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Recent Articles
1.
Author Correction: In vivo base editing extends lifespan of a humanized mouse model of prion disease
An M, Davis J, Levy J, Serack F, Harvey J, Brauer P, et al.
Nat Med
. 2025 Jan;
PMID: 39885360
No abstract available.
2.
An M, Davis J, Levy J, Serack F, Harvey J, Brauer P, et al.
Nat Med
. 2025 Jan;
PMID: 39810005
Prion disease is a fatal neurodegenerative disease caused by the misfolding of prion protein (PrP) encoded by the PRNP gene. While there is currently no cure for the disease, depleting...
3.
Berrios K, Barka A, Gill J, Serrano J, Bailer P, Parker J, et al.
Nucleic Acids Res
. 2024 Jan;
52(4):2078-2090.
PMID: 38261989
The partnership of DNA deaminase enzymes with CRISPR-Cas nucleases is now a well-established method to enable targeted genomic base editing. However, an understanding of how Cas9 and DNA deaminases collaborate...
4.
Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects
Fabyanic E, Hu P, Qiu Q, Berrios K, Connolly D, Wang T, et al.
Nat Biotechnol
. 2023 Aug;
42(6):960-974.
PMID: 37640946
Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET) DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the most abundant form of oxidized 5mC. Existing single-cell bisulfite sequencing methods cannot resolve 5mC and...
5.
Wang T, Fowler J, Liu L, Loo C, Luo M, Schutsky E, et al.
Nat Chem Biol
. 2023 Jun;
19(8):1004-1012.
PMID: 37322153
5-methylcytosine (5mC) is the most important DNA modification in mammalian genomes. The ideal method for 5mC localization would be both nondestructive of DNA and direct, without requiring inference based on...
6.
Serrano J, von Trentini D, Berrios K, Barka A, Dmochowski I, Kohli R
ACS Chem Biol
. 2022 Dec;
17(12):3379-3388.
PMID: 36475588
Nucleic acid structure plays a critical role in governing the selectivity of DNA- and RNA-modifying enzymes. In the case of the APOBEC3 family of cytidine deaminases, these enzymes catalyze the...
7.
Barka A, Berrios K, Bailer P, Schutsky E, Wang T, Kohli R
ACS Chem Biol
. 2022 Mar;
17(3):629-636.
PMID: 35262324
Human APOBEC3A (A3A) is a nucleic acid-modifying enzyme that belongs to the cytidine deaminase family. Canonically, A3A catalyzes the deamination of cytosine into uracil in single-stranded DNA, an activity that...
8.
Berrios K, Evitt N, DeWeerd R, Ren D, Luo M, Barka A, et al.
Nat Chem Biol
. 2021 Oct;
17(12):1262-1270.
PMID: 34663942
DNA deaminase enzymes play key roles in immunity and have recently been harnessed for their biotechnological applications. In base editors (BEs), the combination of DNA deaminase mutator activity with CRISPR-Cas...
9.
Wang T, Luo M, Berrios K, Schutsky E, Wu H, Kohli R
Methods Mol Biol
. 2020 Aug;
2198:349-367.
PMID: 32822044
Here, we provide a detailed protocol for our previously published technique, APOBEC-Coupled Epigenetic Sequencing (ACE-Seq), which localizes 5-hydroxymethylcytosine at single nucleotide resolution using nanogram quantities of input genomic DNA. In...
10.
Grasso M, Estrada M, Berrios K, Winkler J, Marmorstein R
J Med Chem
. 2018 May;
61(11):5034-5046.
PMID: 29727562
BRAF is the most common activating mutation in melanoma and patients treated with BRAF inhibitors all develop resistance within one year. A significant resistance pathway is paradoxical activation (transactivation) involving...