Khelifa Arab
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Explore the profile of Khelifa Arab including associated specialties, affiliations and a list of published articles.
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20
Citations
603
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Recent Articles
1.
Arab K, Niehrs C
Methods Mol Biol
. 2022 Jun;
2528:277-287.
PMID: 35704198
R-loops are three-stranded RNA:DNA hybrid structures that frequently form during transcription. While R-loop misregulation is associated with genome instability, cells also harness RNA-DNA hybrids in scheduled, "regulatory," R-loops to control...
2.
Aparisi Rey A, Karaulanov E, Sharopov S, Arab K, Schafer A, Gierl M, et al.
EMBO Rep
. 2019 Apr;
20(6).
PMID: 30948457
Learning is essential for survival and is controlled by complex molecular mechanisms including regulation of newly synthesized mRNAs that are required to modify synaptic functions. Despite the well-known role of...
3.
Arab K, Karaulanov E, Musheev M, Trnka P, Schafer A, Grummt I, et al.
Nat Genet
. 2019 Jan;
51(2):217-223.
PMID: 30617255
R-loops are DNA-RNA hybrids enriched at CpG islands (CGIs) that can regulate chromatin states. How R-loops are recognized and interpreted by specific epigenetic readers is unknown. Here we show that...
4.
Schomacher L, Han D, Musheev M, Arab K, Kienhofer S, von Seggern A, et al.
Nat Struct Mol Biol
. 2016 Jan;
23(2):116-124.
PMID: 26751644
DNA 5-methylcytosine is a dynamic epigenetic mark with important roles in development and disease. In the Tet-Tdg demethylation pathway, methylated cytosine is iteratively oxidized by Tet dioxygenases, and unmodified cytosine...
5.
Arab K, Park Y, Lindroth A, Schafer A, Oakes C, Weichenhan D, et al.
Mol Cell
. 2014 Aug;
55(4):604-14.
PMID: 25087872
DNA methylation is a dynamic and reversible process that governs gene expression during development and disease. Several examples of active DNA demethylation have been documented, involving genome-wide and gene-specific DNA...
6.
Pedersen M, Schoket B, Godschalk R, Wright J, von Stedingk H, Tornqvist M, et al.
Environ Health Perspect
. 2013 Aug;
121(10):1200-6.
PMID: 23906905
Background: Tobacco-smoke, airborne, and dietary exposures to polycyclic aromatic hydrocarbons (PAHs) have been associated with reduced prenatal growth. Evidence from biomarker-based studies of low-exposed populations is limited. Bulky DNA adducts...
7.
Arab K, Smith L, Gast A, Weichenhan D, Huang J, Claus R, et al.
Carcinogenesis
. 2011 Jul;
32(10):1467-73.
PMID: 21771727
Metastatic melanoma is a fatal disease due to the lack of successful therapies and biomarkers for early detection and its incidence has been increasing. Genetic studies have defined recurrent chromosomal...
8.
Bartsch H, Arab K, Nair J
Environ Health
. 2011 Apr;
10 Suppl 1:S11.
PMID: 21489207
Background: Oxidative stress enhances lipid peroxidation (LPO), which both are implicated in the promotion and progression stages of carcinogenesis, in particular under conditions of chronic inflammation and infections. Exocyclic etheno-DNA...
9.
Nair J, Nair U, Sun X, Wang Y, Arab K, Bartsch H
Methods Mol Biol
. 2010 Nov;
682:189-205.
PMID: 21057929
Exocyclic etheno-DNA adducts are formed by the reaction of lipid peroxidation products, such as 4-hydroxy-2-nonenal (HNE) with DNA bases to yield 1,N (6)-etheno-2'-deoxyadenosine (εdA), 3,-N (4)-etheno-2'-deoxycytidine (εdC), and etheno-2'-deoxyguanosine. These...
10.
Meerang M, Nair J, Sirankapracha P, Thephinlap C, Srichairatanakool S, Arab K, et al.
Int J Cancer
. 2009 May;
125(4):759-66.
PMID: 19480008
In thalassemia patients, iron overload can stimulate lipid peroxidation (LPO), thereby generating miscoding DNA adducts. Adducted DNA was measured in the lymphocytes of beta-Thal/Hb E patients and healthy controls and...