Alpha 2.0
Login Register
» Authors » Khai Phan

Khai Phan

Explore the profile of Khai Phan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 268
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Kenneth A Jacobson
Zhan-Guo Gao
Dilip K Tosh
Francesca Deflorian
Silvia Paoletta
Steven M Moss
Lak Shin Jeong
T Santhosh Kumar
Xiyan Hou
Yoonji Lee
Published In
J Med Chem
ACS Med Chem Lett
Bioorg Med Chem Lett
Biochem Pharmacol
J Am Chem Soc
Affiliations
Soon will be listed here.
Recent Articles
1.
Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary
Lee Y, Hou X, Lee J, Nayak A, Alexander V, Sharma P, et al.
J Med Chem . 2021 Aug; 64(17):12525-12536. PMID: 34435786
Distinguishing compounds' agonistic or antagonistic behavior would be of great utility for the rational discovery of selective modulators. We synthesized truncated nucleoside derivatives and discovered ( = 2.40 nM) as...
2.
Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects
Dix A, Moss S, Phan K, Hoppe T, Paoletta S, Kozma E, et al.
J Am Chem Soc . 2014 Aug; 136(35):12296-303. PMID: 25116377
A programmable ligand display system can be used to dissect the multivalent effects of ligand binding to a membrane receptor. An antagonist of the A2A adenosine receptor, a G-protein-coupled receptor...
3.
Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists
Nayak A, Chandra G, Hwang I, Kim K, Hou X, Kim H, et al.
J Med Chem . 2014 Jan; 57(4):1344-54. PMID: 24456490
Truncated N(6)-substituted-(N)-methanocarba-adenosine derivatives with 2-hexynyl substitution were synthesized to examine parallels with corresponding 4'-thioadenosines. Hydrophobic N(6) and/or C2 substituents were tolerated in A3AR binding, but only an unsubstituted 6-amino group...
4.
Structure-activity relationships and molecular modeling of 1,2,4-triazoles as adenosine receptor antagonists
Carlsson J, Tosh D, Phan K, Gao Z, Jacobson K
ACS Med Chem Lett . 2013 Jan; 3(9):715-720. PMID: 23342198
The structure-activity relationship (SAR) for a novel class of 1,2,4-triazole antagonists of the human A(2A) adenosine receptor (hA(2A)AR) was explored. Thirty-three analogs of a ligand that was discovered in a...
5.
Limits of ligand selectivity from docking to models: in silico screening for A(1) adenosine receptor antagonists
Kolb P, Phan K, Gao Z, Marko A, Sali A, Jacobson K
PLoS One . 2012 Nov; 7(11):e49910. PMID: 23185482
G protein-coupled receptors (GPCRs) are attractive targets for pharmaceutical research. With the recent determination of several GPCR X-ray structures, the applicability of structure-based computational methods for ligand identification, such as...
6.
Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles
Jayasekara P, Phan K, Tosh D, Kumar T, Moss S, Zhang G, et al.
Purinergic Signal . 2012 Nov; 9(2):183-98. PMID: 23179047
Gold nanoparticles (AuNPs) allow the tuning of pharmacokinetic and pharmacodynamic properties by active or passive targeting of drugs for cancer and other diseases. We have functionalized gold nanoparticles by tethering...
7.
Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions
Tosh D, Paoletta S, Phan K, Gao Z, Jacobson K
ACS Med Chem Lett . 2012 Nov; 3(7):596-601. PMID: 23145215
C2-Arylethynyladenosine-5'-N-methyluronamides containing a bicyclo[3.1.0]hexane ((N)-methanocarba) ring are selective A(3) adenosine receptor (AR) agonists. Similar 4'-truncated C2-arylethynyl-(N)-methanocarba nucleosides containing alkyl or alkylaryl groups at the N(6) position were low-efficacy agonists or...
8.
Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity
Tosh D, Paoletta S, Deflorian F, Phan K, Moss S, Gao Z, et al.
J Med Chem . 2012 Aug; 55(18):8075-90. PMID: 22921089
A(1) adenosine receptor (AR) agonists display antiischemic and antiepileptic neuroprotective activity, but peripheral cardiovascular side effects impeded their development. SAR study of N(6)-cycloalkylmethyl 4'-truncated (N)-methanocarba-adenosines identified 10 (MRS5474, N(6)-dicyclopropylmethyl, K(i)...
9.
Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions
Tosh D, Deflorian F, Phan K, Gao Z, Wan T, Gizewski E, et al.
J Med Chem . 2012 May; 55(10):4847-60. PMID: 22559880
(N)-Methanocarba adenosine 5'-methyluronamides containing known A(3) AR (adenosine receptor)-enhancing modifications, i.e., 2-(arylethynyl)adenine and N(6)-methyl or N(6)-(3-substituted-benzyl), were nanomolar full agonists of human (h) A(3)AR and highly selective (K(i) ∼0.6 nM,...
10.
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening
Tosh D, Phan K, Gao Z, Gakh A, Xu F, Deflorian F, et al.
J Med Chem . 2012 Apr; 55(9):4297-308. PMID: 22486652
Structures of G protein-coupled receptors (GPCRs) have a proven utility in the discovery of new antagonists and inverse agonists modulating signaling of this important family of clinical targets. Applicability of...