Xiyan Hou
Overview
Explore the profile of Xiyan Hou including associated specialties, affiliations and a list of published articles.
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29
Citations
240
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Recent Articles
1.
Kim G, Jarhad D, Lee G, Kim G, Hou X, Yu J, et al.
J Med Chem
. 2024 Jun;
67(12):10490-10507.
PMID: 38845345
Building on the preceding structural analysis and a structure-activity relationship (SAR) of 8-aryl-2-hexynyl nucleoside hAAR antagonist , we strategically inverted C2/C8 substituents and eliminated the ribose moiety. These modifications aimed...
2.
Kim G, Hou X, Byun W, Kim G, Jarhad D, Lee G, et al.
J Med Chem
. 2024 Jan;
67(3):2236.
PMID: 38259147
No abstract available.
3.
Kim G, Hou X, Byun W, Kim G, Jarhad D, Lee G, et al.
J Med Chem
. 2023 Aug;
66(17):12249-12265.
PMID: 37603705
Based on hAAR structures, a hydrophobic C8-heteroaromatic ring in 5'-truncated adenosine analogues occupies the subpocket tightly, converting hAAR agonists into antagonists while maintaining affinity toward hAAR. The final compounds of...
4.
Shiriaeva A, Park D, Kim G, Lee Y, Hou X, Jarhad D, et al.
J Med Chem
. 2022 Aug;
65(17):11648-11657.
PMID: 35977382
Modulators of the G protein-coupled A adenosine receptor (AAR) have been considered promising agents to treat Parkinson's disease, inflammation, cancer, and central nervous system disorders. Herein, we demonstrate that a...
5.
Wu W, Wang L, Yang Y, Du W, Ji W, Fang Z, et al.
Biosens Bioelectron
. 2022 May;
210:114328.
PMID: 35512583
Optical flexible biosensors are novel sensors fabricated on flexible or ductile materials that are used for the detection of analytes. Compared to traditional sensors, these biosensors offer greater flexibility, which...
6.
Zhang L, Jin M, Shi X, Jin L, Hou X, Yu Y, et al.
Appl Biochem Biotechnol
. 2022 Feb;
194(6):2581-2593.
PMID: 35175565
A total of 172 microbial strains were screened and isolated from Arctic Ocean marine sediments at a depth of 42 ~ 3,763 m. A microorganism with strong antibacterial activity against...
7.
Li J, Zhang W, Ji W, Wang J, Wang N, Wu W, et al.
J Mater Chem B
. 2021 Oct;
9(38):7909-7926.
PMID: 34611678
Photothermal therapy (PTT) has been widely applied in cancer therapy as a result of its non-invasive, localized treatment and good therapeutic effect. In general, the final therapeutic effect of PTT...
8.
Lee Y, Hou X, Lee J, Nayak A, Alexander V, Sharma P, et al.
J Med Chem
. 2021 Aug;
64(17):12525-12536.
PMID: 34435786
Distinguishing compounds' agonistic or antagonistic behavior would be of great utility for the rational discovery of selective modulators. We synthesized truncated nucleoside derivatives and discovered ( = 2.40 nM) as...
9.
Pak E, Jeong L, Hou X, Tripathi S, Lee J, Ha H
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34073488
Kidney fibrosis is the final outcome of chronic kidney disease (CKD). Adenosine plays a significant role in protection against cellular damage by activating four subtypes of adenosine receptors (ARs), AAR,...
10.
Ye Q, Hou X, Lee H, Liu H, Lu L, Wu X, et al.
Chempluschem
. 2020 Jun;
85(6):1339-1346.
PMID: 32578958
The development of efficient and low-cost oxygen evolution reaction (OER) catalysts is essential for the generation of clean hydrogen energy from water splitting. Herein, a novel hierarchical urchin-like cobalt-copper (hydr)oxide...