Kevork Hagopian
Overview
Explore the profile of Kevork Hagopian including associated specialties, affiliations and a list of published articles.
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35
Citations
922
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Recent Articles
1.
Zhou Z, Hagopian K, Lopez-Dominguez J, Kim K, Jasoliya M, Roberts M, et al.
Aging (Albany NY)
. 2021 Mar;
13(6):7914-7930.
PMID: 33735837
Declines in mitochondrial mass are thought to be a hallmark of mammalian aging, and a ketogenic diet (KD) may prevent the age-related decreases in mitochondrial content. The objective of this...
2.
Roberts M, Wallace M, Tomilov A, Zhou Z, Marcotte G, Tran D, et al.
Cell Metab
. 2018 May;
27(5):1156.
PMID: 29719228
No abstract available.
3.
Roberts M, Wallace M, Tomilov A, Zhou Z, Marcotte G, Tran D, et al.
Cell Metab
. 2017 Sep;
26(3):539-546.e5.
PMID: 28877457
Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this...
4.
Hagopian K, Kim K, Lopez-Dominguez J, Tomilov A, Cortopassi G, Ramsey J
Biochem Biophys Rep
. 2017 Jan;
7:273-286.
PMID: 28133633
Shc proteins play a role in energy metabolism through interaction with the insulin receptor. The aim of this study was to determine whether Shc proteins influence liver glycolysis and gluconeogenesis...
5.
Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, et al.
J Biol Chem
. 2016 Apr;
291(24):12575-12585.
PMID: 27059956
Although the p46Shc isoform has been known to be mitochondrially localized for 11 years, its function in mitochondria has been a mystery. We confirmed p46Shc to be mitochondrially localized and...
6.
Hagopian K, Tomilov A, Kim K, Cortopassi G, Ramsey J
PLoS One
. 2015 Apr;
10(4):e0124204.
PMID: 25880638
Shc proteins interact with the insulin receptor, indicating a role in regulating glycolysis. To investigate this idea, the activities of key glycolytic regulatory enzymes and metabolites levels were measured in...
7.
Villalba J, Lopez-Dominguez J, Chen Y, Khraiwesh H, Gonzalez-Reyes J, Fernandez Del Rio L, et al.
Biogerontology
. 2015 Apr;
16(5):655-70.
PMID: 25860863
The Membrane Theory of Aging proposes that lifespan is inversely related to the level of unsaturation in membrane phospholipids. Calorie restriction (CR) without malnutrition extends lifespan in many model organisms,...
8.
Lopez-Dominguez J, Ramsey J, Tran D, Imai D, Koehne A, Laing S, et al.
J Gerontol A Biol Sci Med Sci
. 2014 Oct;
70(10):1181-8.
PMID: 25313149
Calorie restriction (CR) without malnutrition extends life span in several animal models. It has been proposed that a decrease in the amount of polyunsaturated fatty acids (PUFAs), and especially n-3...
9.
Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, et al.
Aging Cell
. 2014 Sep;
13(6):1049-58.
PMID: 25257068
Adipose tissue is an important metabolic organ that integrates a wide array of homeostatic processes and is crucial for whole-body insulin sensitivity and energy metabolism. Brown adipose tissue (BAT) is...
10.
Ramsey J, Tran D, Giorgio M, Griffey S, Koehne A, Laing S, et al.
J Gerontol A Biol Sci Med Sci
. 2013 Dec;
69(10):1177-85.
PMID: 24336818
The signaling molecule p66Shc is often described as a longevity protein. This conclusion is based on a single life span study that used a small number of mice. The purpose...