Kevin Tidgewell
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Explore the profile of Kevin Tidgewell including associated specialties, affiliations and a list of published articles.
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21
Citations
570
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Recent Articles
1.
Lei S, Lu J, Cheng A, Hussain Z, Tidgewell K, Zhu J, et al.
Drug Metab Dispos
. 2023 Feb;
51(5):629-636.
PMID: 36797057
(Gou Teng) and (cat's claw) are frequently used herbal supplements in Asia and America, respectively. Despite their common usage, information is limited regarding potential herb-drug interactions associated with Gou Teng...
2.
Rague A, Tidgewell K
Mini Rev Med Chem
. 2017 Sep;
18(7):552-560.
PMID: 28901854
The serotonin system exerts its effects on the CNS and many peripheral systems. Of the 14 serotonin receptors, the 5-HT7 receptor is the most recently discovered. The 5-HT7 receptor has...
3.
Balunas M, Grosso M, Villa F, Engene N, McPhail K, Tidgewell K, et al.
Org Lett
. 2012 Jul;
14(15):3878-81.
PMID: 22794317
Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, either a...
4.
Lamb K, Tidgewell K, Simpson D, Bohn L, Prisinzano T
Drug Alcohol Depend
. 2011 Nov;
121(3):181-8.
PMID: 22119134
Herkinorin is the first μ opioid (MOP) selective agonist derived from salvinorin A, a hallucinogenic natural product. Previous work has shown that, unlike other opioids, herkinorin does not promote the...
5.
Tidgewell K, Engene N, Byrum T, Media J, Doi T, Valeriote F, et al.
Chembiochem
. 2010 Jun;
11(10):1458-66.
PMID: 20512792
A collection of Lyngbya bouillonii from Palmyra Atoll in the Central Pacific, a site several thousand kilometers distant from all previous collections of this chemically prolific species of cyanobacterium, was...
6.
Gutierrez M, Tidgewell K, Capson T, Engene N, Almanza A, Schemies J, et al.
J Nat Prod
. 2010 Feb;
73(4):709-11.
PMID: 20158242
Fractionation of the extract of the marine cyanobacterium Lyngbya majuscula collected from Panama led to the isolation of malyngolide dimer (1). The planar structure of 1 was determined using 1D...
7.
Balunas M, Linington R, Tidgewell K, Fenner A, Urena L, Della Togna G, et al.
J Nat Prod
. 2009 Dec;
73(1):60-6.
PMID: 20030365
Tropical parasitic and infectious diseases, such as leishmaniasis, pose enormous global health threats, but are largely neglected in commercial drug discovery programs. However, the Panama International Cooperative Biodiversity Group (ICBG)...
8.
Tidgewell K, Groer C, Harding W, Lozama A, Schmidt M, Marquam A, et al.
J Med Chem
. 2008 Apr;
51(8):2421-31.
PMID: 18380425
Salvinorin A is a psychoactive natural product that has been found to be a potent and selective kappa opioid receptor agonist in vitro and in vivo. The activity of salvinorin...
9.
Holden K, Tidgewell K, Marquam A, Rothman R, Navarro H, Prisinzano T
Bioorg Med Chem Lett
. 2007 Oct;
17(22):6111-5.
PMID: 17904842
Modification of the C-1 ketone of salvinorin A (2a) produces analogues with opioid antagonist properties. Of particular significance is the finding that 1-deoxo-1,10-dehydrosalvinorin A (11a) is a moderately potent antagonist...
10.
Xu H, Partilla J, Wang X, Rutherford J, Tidgewell K, Prisinzano T, et al.
Synapse
. 2006 Dec;
61(3):166-75.
PMID: 17152090
Previous studies established that Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol (DAMGO) and (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester (herkinorin) are fully efficacious mu-agonists. Herkinorin (HERK), unlike DAMGO, does not recruit beta-arrestin and promote mu-receptor internalization, even in...