Kevin S Lang
Overview
Explore the profile of Kevin S Lang including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
424
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0
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Recent Articles
1.
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids
Stoy H, Zwicky K, Kuster D, Lang K, Krietsch J, Crossley M, et al.
Nat Struct Mol Biol
. 2023 Mar;
30(3):348-359.
PMID: 36864174
Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-loops were linked to head-on TRCs and proposed to obstruct replication fork progression. The underlying mechanisms, however, remained elusive due to...
2.
Park M, Kim J, Feinstein J, Lang K, Ryu S, Jeon B
Microbiol Spectr
. 2022 Sep;
10(5):e0166722.
PMID: 36066254
Antibiotic tolerance not only enables bacteria to survive acute antibiotic exposures but also provides bacteria with a window of time in which to develop antibiotic resistance. The increasing prevalence of...
3.
Stoy H, Lang K, Merrikh H, Lopes M
Methods Mol Biol
. 2022 Jun;
2528:67-89.
PMID: 35704186
DNA-RNA hybrids can interfere with DNA replication, but the underlying intermediates and molecular mechanisms have remained elusive. Here, we describe a single molecule approach that allows to monitor DNA-RNA hybrids...
4.
Lang K, Merrikh H
Cell Rep
. 2021 Mar;
34(9):108797.
PMID: 33657379
Conflicts between the replication and transcription machineries have profound effects on chromosome duplication, genome organization, and evolution across species. Head-on conflicts (lagging-strand genes) are significantly more detrimental than codirectional conflicts...
5.
Ma D, Wang Z, Merrikh C, Lang K, Lu P, Li X, et al.
Nature
. 2018 Oct;
562(7726):286-290.
PMID: 30283133
Membrane-bound O-acyltransferases (MBOATs) are a superfamily of integral transmembrane enzymes that are found in all kingdoms of life. In bacteria, MBOATs modify protective cell-surface polymers. In vertebrates, some MBOAT enzymes-such...
6.
Lang K, Merrikh H
Annu Rev Microbiol
. 2018 Jun;
72:71-88.
PMID: 29856930
Within the last decade, it has become clear that DNA replication and transcription are routinely in conflict with each other in growing cells. Much of the seminal work on this...
7.
Lang K, Hall A, Merrikh C, Ragheb M, Tabakh H, Pollock A, et al.
Cell
. 2017 Aug;
170(4):787-799.e18.
PMID: 28802046
Replication-transcription collisions shape genomes, influence evolution, and promote genetic diseases. Although unclear why, head-on transcription (lagging strand genes) is especially disruptive to replication and promotes genomic instability. Here, we find...
8.
Lang K, Johnson T
Plasmid
. 2016 Aug;
87-88:17-27.
PMID: 27492737
Conjugation plays an important role in the horizontal movement of DNA between bacterial species and even genera. Large conjugative plasmids in Gram-negative bacteria are associated with multi-drug resistance and have...
9.
LaPara T, Madson M, Borchardt S, Lang K, Johnson T
Environ Sci Technol
. 2015 Sep;
49(19):11509-15.
PMID: 26325533
This study evaluated multiple discharges of treated wastewater on the quantities of antibiotic resistance genes (ARGs) in the Upper Mississippi River. Surface water and treated wastewater samples were collected along...
10.
Lang K, Johnson T
Plasmid
. 2015 Jun;
80:83-9.
PMID: 26079188
Plasmids play an important role in driving the genetic diversity of bacteria. Horizontal gene transfer via plasmids is crucial for the dissemination of antimicrobial resistance genes. Many factors contribute to...