Jana Krietsch
Overview
Explore the profile of Jana Krietsch including associated specialties, affiliations and a list of published articles.
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20
Citations
1041
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Recent Articles
1.
Palumbieri M, Merigliano C, Gonzalez-Acosta D, Kuster D, Krietsch J, Stoy H, et al.
Nat Commun
. 2023 Nov;
14(1):7819.
PMID: 38016948
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using...
2.
Chanou A, WeiB M, Holler K, Sajid A, Straub T, Krietsch J, et al.
Nucleic Acids Res
. 2023 Nov;
51(22):12303-12324.
PMID: 37956271
Stochastic origin activation gives rise to significant cell-to-cell variability in the pattern of genome replication. The molecular basis for heterogeneity in efficiency and timing of individual origins is a long-standing...
3.
Palumbieri M, Merigliano C, Acosta D, von Kanel T, Welter B, Stoy H, et al.
bioRxiv
. 2023 Mar;
PMID: 36993227
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using...
4.
Martin E, Rodriguez Y Baena A, Reggiardo R, Worthington A, Mattingly C, Poscablo D, et al.
Stem Cells
. 2023 Mar;
41(5):520-539.
PMID: 36945732
Epigenetic mechanisms regulate the multilineage differentiation capacity of hematopoietic stem cells (HSCs) into a variety of blood and immune cells. Mapping the chromatin dynamics of functionally defined cell populations will...
5.
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids
Stoy H, Zwicky K, Kuster D, Lang K, Krietsch J, Crossley M, et al.
Nat Struct Mol Biol
. 2023 Mar;
30(3):348-359.
PMID: 36864174
Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-loops were linked to head-on TRCs and proposed to obstruct replication fork progression. The underlying mechanisms, however, remained elusive due to...
6.
Jacobs K, Doerdelmann C, Krietsch J, Gonzalez-Acosta D, Mathis N, Kushinsky S, et al.
Mol Cell
. 2022 Sep;
82(21):4176-4188.e8.
PMID: 36152632
Stem cell division is linked to tumorigenesis by yet-elusive mechanisms. The hematopoietic system reacts to stress by triggering hematopoietic stem and progenitor cell (HSPC) proliferation, which can be accompanied by...
7.
Rodriguez Y Baena A, Rajendiran S, Manso B, Krietsch J, Boyer S, Kirschmann J, et al.
Sci Rep
. 2022 Feb;
12(1):3156.
PMID: 35210475
Hematopoietic stem cell (HSC) multipotency and self-renewal are typically defined through serial transplantation experiments. Host conditioning is necessary for robust HSC engraftment, likely by reducing immune-mediated rejection and by clearing...
8.
Martin E, Krietsch J, Reggiardo R, Sousae R, Kim D, Forsberg E
Epigenetics Chromatin
. 2021 Jan;
14(1):2.
PMID: 33407811
Hematopoietic stem cells (HSCs) have the capacity to differentiate into vastly different types of mature blood cells. The epigenetic mechanisms regulating the multilineage ability, or multipotency, of HSCs are not...
9.
Berti M, Teloni F, Mijic S, Ursich S, Fuchs J, Palumbieri M, et al.
Nat Commun
. 2020 Jul;
11(1):3531.
PMID: 32669601
Homologous recombination (HR) factors were recently implicated in DNA replication fork remodeling and protection. While maintaining genome stability, HR-mediated fork remodeling promotes cancer chemoresistance, by as-yet elusive mechanisms. Five HR...
10.
Rainey M, Quinlan A, Cazzaniga C, Mijic S, Martella O, Krietsch J, et al.
EMBO Rep
. 2020 Jun;
21(8):e48920.
PMID: 32496651
The CDC7 kinase is essential for the activation of DNA replication origins and has been implicated in the replication stress response. Using a highly specific chemical inhibitor and a chemical...