Kevin Roarty
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Explore the profile of Kevin Roarty including associated specialties, affiliations and a list of published articles.
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20
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1117
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Recent Articles
11.
Rosen J, Roarty K
Breast Cancer Res
. 2014 Jan;
16(1):202.
PMID: 24476463
Paracrine signaling mechanisms play a critical role in both normal mammary gland development and breast cancer. Dissection of these mechanisms using genetically engineered mouse models has provided significant insight into...
12.
Roarty K, Rosen J
Breast Cancer Res
. 2013 Dec;
15(6):322.
PMID: 24365076
The mammary gland requires the coordinated efforts of multiple epithelial cell lineages to build an organized bilayered ductal network. How epigenetic regulators direct decisions of cell-fate and lineage determination in...
13.
Pond A, Bin X, Batts T, Roarty K, Hilsenbeck S, Rosen J
Stem Cells
. 2012 Oct;
31(1):178-89.
PMID: 23097355
Fibroblast growth factor (FGF) signaling plays an important role in embryonic stem cells and adult tissue homeostasis, but the function of FGFs in mammary gland stem cells is less well...
14.
Shore A, Kabotyanski E, Roarty K, Smith M, Zhang Y, Creighton C, et al.
PLoS Genet
. 2012 Aug;
8(7):e1002840.
PMID: 22911650
Pregnancy-induced noncoding RNA (PINC) and retinoblastoma-associated protein 46 (RbAp46) are upregulated in alveolar cells of the mammary gland during pregnancy and persist in alveolar cells that remain in the regressed...
15.
Meerbrey K, Hu G, Kessler J, Roarty K, Li M, Fang J, et al.
Proc Natl Acad Sci U S A
. 2011 Feb;
108(9):3665-70.
PMID: 21307310
The discovery of RNAi has revolutionized loss-of-function genetic studies in mammalian systems. However, significant challenges still remain to fully exploit RNAi for mammalian genetics. For instance, genetic screens and in...
16.
Roarty K, Rosen J
Curr Opin Pharmacol
. 2010 Sep;
10(6):643-9.
PMID: 20810315
The mammary stem cell and its local microenvironment are central for the maintenance of proper tissue homeostasis during normal development. Defining the hierarchical organization of the epithelial subtypes in the...
17.
Qin H, Wang L, Feng T, Elson C, Niyongere S, Lee S, et al.
J Immunol
. 2009 Jun;
183(1):97-105.
PMID: 19535626
TGF-beta, together with IL-6 and IL-21, promotes Th17 cell development. IL-6 and IL-21 induce activation of STAT3, which is crucial for Th17 cell differentiation, as well as the expression of...
18.
Roarty K, Baxley S, Crowley M, Frost A, Serra R
Breast Cancer Res
. 2009 Apr;
11(2):R19.
PMID: 19344510
Introduction: The tumour-suppressive effects of transforming growth factor-beta (TGF-beta) are well documented; however, the mechanistic basis of these effects is not fully understood. Previously, we showed that a non-canonical member...
19.
Brantley E, Nabors L, Gillespie G, Choi Y, Palmer C, Harrison K, et al.
Clin Cancer Res
. 2008 Aug;
14(15):4694-704.
PMID: 18676737
Purpose: STATs activate transcription in response to numerous cytokines, controlling proliferation, gene expression, and apoptosis. Aberrant activation of STAT proteins, particularly STAT-3, is implicated in the pathogenesis of many cancers,...
20.
Johnson E, Nicola T, Roarty K, Yoder B, Haycraft C, Serra R
Dev Dyn
. 2008 Jul;
237(8):2053-60.
PMID: 18629867
Ift88 is a component of the intraflagellar transport complex required for formation and maintenance of cilia. Disruption of Ift88 results in depletion of cilia. The goal of the current study...