Kevin Roarty
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Explore the profile of Kevin Roarty including associated specialties, affiliations and a list of published articles.
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1117
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Recent Articles
1.
Si H, Mendoza Mendoza E, Esquivel M, Creighton C, Xu J, Roarty K
bioRxiv
. 2025 Mar;
PMID: 40060578
The mammary gland epithelium relies on a delicate balance between basal and luminal cell lineages to maintain tissue homeostasis and enable proper development. While the role of canonical Wnt signaling...
2.
Si H, Esquivel M, Mendoza Mendoza E, Roarty K
Front Cell Dev Biol
. 2023 Jul;
11:1221784.
PMID: 37440925
Breast cancer has emerged as the most commonly diagnosed cancer and primary cause of cancer-related deaths among women worldwide. Although significant progress has been made in targeting the primary tumor,...
3.
Roarty K
Dev Cell
. 2023 Jul;
58(13):1123-1125.
PMID: 37433279
In this issue of Developmental Cell, Pfannenstein and Macara leverage the experimental versatility of the mammary gland to show that intercalation within the terminal end bud is regulated by the...
4.
Roarty K
Cell Stem Cell
. 2023 Jun;
30(6):743-744.
PMID: 37267909
In this issue of Cell Stem Cell, Beziaud et al. show that immunotherapy induces stem-like properties in models of breast cancer. Strikingly, T-cell-derived IFNγ promotes cancer stem cell (CSC) phenotypes,...
5.
Si H, Zhao N, Pedroza A, Zaske A, Rosen J, Creighton C, et al.
Mol Biol Cell
. 2022 Aug;
33(11):ar103.
PMID: 36001375
Cell-extracellular matrix (ECM) interactions represent fundamental exchanges during tumor progression, yet how particular signal-transduction factors prompt the conversion of tumor cells into migratory populations capable of systemic spread during metastasis...
6.
Roarty K, Echeverria G
Front Oncol
. 2021 Mar;
11:645698.
PMID: 33777805
While numerous therapies are highly efficacious in early-stage breast cancers and in particular subsets of breast cancers, therapeutic resistance and metastasis unfortunately arise in many patients. In many cases, tumors...
7.
Sreekumar A, Toneff M, Toh E, Roarty K, Creighton C, Belka G, et al.
Dev Cell
. 2017 Nov;
43(4):436-448.e6.
PMID: 29103953
Puberty is characterized by dynamic tissue remodeling in the mammary gland involving ductal elongation, resolution into the mature epithelial bilayer, and lumen formation. To decipher the cellular mechanisms underlying these...
8.
Sreekumar A, Roarty K, Rosen J
Endocr Relat Cancer
. 2015 Jul;
22(6):T161-76.
PMID: 26206777
The mammary gland is a dynamic organ that undergoes extensive morphogenesis during the different stages of embryonic development, puberty, estrus, pregnancy, lactation and involution. Systemic and local cues underlie this...
9.
Roarty K, Shore A, Creighton C, Rosen J
J Cell Biol
. 2015 Jan;
208(3):351-66.
PMID: 25624393
Wnt signaling encompasses β-catenin-dependent and -independent networks. How receptor context provides Wnt specificity in vivo to assimilate multiple concurrent Wnt inputs throughout development remains unclear. Here, we identified a refined...
10.
Wei W, Tweardy D, Zhang M, Zhang X, Landua J, Petrovic I, et al.
Stem Cells
. 2014 Jun;
32(10):2571-82.
PMID: 24891218
In breast cancer, a subset of tumor-initiating cells (TIC) or "cancer stem cells" are thought to be responsible for tumor maintenance, treatment resistance, and disease recurrence. While current breast cancer...