Kevin R Thornton
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Explore the profile of Kevin R Thornton including associated specialties, affiliations and a list of published articles.
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2609
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Recent Articles
1.
Ragsdale A, Thornton K
Mol Biol Evol
. 2023 Jul;
40(8).
PMID: 37450583
Wang et al. (2023) recently proposed an approach to infer the history of human generation intervals from changes in mutation profiles over time. As the relative proportions of different mutation...
2.
Gower G, Ragsdale A, Bisschop G, Gutenkunst R, Hartfield M, Noskova E, et al.
Genetics
. 2022 Sep;
222(3).
PMID: 36173327
Understanding the demographic history of populations is a key goal in population genetics, and with improving methods and data, ever more complex models are being proposed and tested. Demographic models...
3.
Thornton K
Genetics
. 2019 Oct;
213(4):1513-1530.
PMID: 31653678
Predictions about the effect of natural selection on patterns of linked neutral variation are largely based on models involving the rapid fixation of unconditionally beneficial mutations. However, when phenotypes adapt...
4.
Kelleher J, Thornton K, Ashander J, Ralph P
PLoS Comput Biol
. 2018 Nov;
14(11):e1006581.
PMID: 30383757
In this paper we describe how to efficiently record the entire genetic history of a population in forwards-time, individual-based population genetics simulations with arbitrary breeding models, population structure and demography....
5.
Sanjak J, Sidorenko J, Robinson M, Thornton K, Visscher P
Proc Natl Acad Sci U S A
. 2017 Dec;
115(1):151-156.
PMID: 29255044
Modern molecular genetic datasets, primarily collected to study the biology of human health and disease, can be used to directly measure the action of natural selection and reveal important features...
6.
Rogers R, Shao L, Thornton K
PLoS Genet
. 2017 May;
13(5):e1006795.
PMID: 28531189
One common hypothesis to explain the impacts of tandem duplications is that whole gene duplications commonly produce additive changes in gene expression due to copy number changes. Here, we use...
7.
Sanjak J, Long A, Thornton K
PLoS Genet
. 2017 Jan;
13(1):e1006573.
PMID: 28103232
The genetic component of complex disease risk in humans remains largely unexplained. A corollary is that the allelic spectrum of genetic variants contributing to complex disease risk is unknown. Theoretical...
8.
Sanjak J, Long A, Thornton K
G3 (Bethesda)
. 2016 Feb;
6(4):1023-30.
PMID: 26865700
Genome-wide association studies (GWAS) have associated many single variants with complex disease, yet the better part of heritable complex disease risk remains unexplained. Analytical tools designed to work under specific...
9.
Tandem Duplications and the Limits of Natural Selection in Drosophila yakuba and Drosophila simulans
Rogers R, Cridland J, Shao L, Hu T, Andolfatto P, Thornton K
PLoS One
. 2015 Jul;
10(7):e0132184.
PMID: 26176952
Tandem duplications are an essential source of genetic novelty, and their variation in natural populations is expected to influence adaptive walks. Here, we describe evolutionary impacts of recently-derived, segregating tandem...
10.
Cridland J, Thornton K, Long A
Genetics
. 2014 Oct;
199(1):85-93.
PMID: 25335504
Transposable elements are a common source of genetic variation that may play a substantial role in contributing to gene expression variation. However, the contribution of transposable elements to expression variation...