David R Lamson
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Explore the profile of David R Lamson including associated specialties, affiliations and a list of published articles.
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8
Citations
37
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Recent Articles
1.
Lamson D, Tarpley M, Addo K, Ji X, Abu Rabe D, Ehe B, et al.
Biochim Biophys Acta Gen Subj
. 2024 Aug;
1868(11):130692.
PMID: 39151833
Sonic hedgehog (Shh) is a morphogen with important roles in embryonic development and in the development of a number of cancers. Its activity is modulated by interactions with binding partners...
2.
Abu Rabe D, Chdid L, Lamson D, Laudeman C, Tarpley M, Elsayed N, et al.
Molecules
. 2024 Jul;
29(13.
PMID: 38999049
Aberrant activation of hedgehog (Hh) signaling has been implicated in various cancers. Current FDA-approved inhibitors target the seven-transmembrane receptor Smoothened, but resistance to these drugs has been observed. It has...
3.
Lamson D, Hughes M, Adcock A, Smith G, Williams K
MethodsX
. 2021 Aug;
8:101207.
PMID: 34434730
Sonic hedgehog (Shh) is a morphogenic protein with critical roles in embryogenesis and the development of some cancers. Hence, identifying inhibitors of the Shh pathway is of great therapeutic value....
4.
Ehe B, Lamson D, Tarpley M, Onyenwoke R, Graves L, Williams K
Data Brief
. 2017 Oct;
15:577-583.
PMID: 29071296
The data presented in this article support the accompanying research article "Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1" (Ehe et...
5.
Ehe B, Lamson D, Tarpley M, Onyenwoke R, Graves L, Williams K
Biochem Biophys Res Commun
. 2017 Jul;
491(3):767-772.
PMID: 28735864
GLI1 is a key downstream transcription effector of the Hedgehog (Hh) signaling pathway that is involved in promoting cell growth, differentiation and tissue patterning in embryonic development. GLI1 over-activation and...
6.
Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening
Brantley S, Cotten S, Lamson D, Smith G, Liu R, Williams K
Biochem Biophys Res Commun
. 2017 Jul;
491(3):773-779.
PMID: 28733033
C. elegans has been widely used as a model organism for programmed cell death and apoptosis. Although the CED-3 caspase is the primary effector of cell death in C. elegans,...
7.
Sexton J, Danshina P, Lamson D, Hughes M, House A, Yeh L, et al.
Curr Chem Genomics
. 2011 Jul;
5:30-41.
PMID: 21760877
Glycolytic isozymes that are restricted to the male germline are potential targets for the development of reversible, non-hormonal male contraceptives. GAPDHS, the sperm-specific isoform of glyceraldehyde-3-phosphate dehydrogenase, is an essential...
8.
Lamson D, House A, Danshina P, Sexton J, Sanyang K, OBrien D, et al.
Protein Expr Purif
. 2010 Sep;
75(1):104-13.
PMID: 20828617
The sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) isoform is a promising contraceptive target because it is specific to male germ cells, essential for sperm motility and male fertility, and well suited to...