Kevin M Woolfrey
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Explore the profile of Kevin M Woolfrey including associated specialties, affiliations and a list of published articles.
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27
Citations
1948
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Recent Articles
1.
Koster K, Fyke Z, Nguyen T, Niqula A, Noriega-Gonzalez L, Woolfrey K, et al.
Front Synaptic Neurosci
. 2024 May;
16:1384625.
PMID: 38798824
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), is associated with the devastating...
2.
Martinez T, Larsen M, Sullivan E, Woolfrey K, DellAcqua M
eNeuro
. 2024 Feb;
PMID: 38331575
Alzheimer's Disease (AD) is associated with brain accumulation of synaptotoxic amyloid-β (Aβ) peptides produced by the proteolytic processing of amyloid precursor protein (APP). Cognitive impairments associated with AD correlate with...
3.
Jones K, Sumiya M, Woolfrey K, Srivastava D, Penzes P
Mol Cell Neurosci
. 2019 May;
98:19-31.
PMID: 31059774
EPAC2 is a guanine nucleotide exchange factor that regulates GTPase activity of the small GTPase Rap and Ras and is highly enriched at synapses. Activation of EPAC2 has been shown...
4.
Gibson E, Woolfrey K, Li H, Hogan P, Nemenoff R, Heasley L, et al.
Mol Pharmacol
. 2018 Nov;
95(1):20-32.
PMID: 30404891
Calcineurin (CaN) phosphatase signaling is regulated by targeting CaN to substrates, inhibitors, and scaffold proteins containing docking motifs with the consensus sequence of PxIxIT. Here, we identify the docking of...
5.
Purkey A, Woolfrey K, Crosby K, Stich D, Chick W, Aoto J, et al.
Cell Rep
. 2018 Oct;
25(4):974-987.e4.
PMID: 30355502
Ca-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term potentiation (LTP), but mechanisms regulating CP-AMPARs are poorly understood. A-kinase...
6.
Eisinger K, Woolfrey K, Swanson S, Schnell S, Meitzen J, DellAcqua M, et al.
J Biol Chem
. 2018 Aug;
293(41):15901-15911.
PMID: 30158247
Palmitoylation is a reversible post-translational addition of a 16-carbon lipid chain involved in trafficking and compartmentalizing target proteins. It is important for many cellular functions, including signaling via membrane-localized estrogen...
7.
DellAcqua M, Woolfrey K
Nat Neurosci
. 2018 Jul;
21(8):1021-1022.
PMID: 30013172
No abstract available.
8.
Woolfrey K, OLeary H, Goodell D, Robertson H, Horne E, Coultrap S, et al.
J Biol Chem
. 2017 Dec;
293(5):1551-1567.
PMID: 29196604
Both long-term potentiation (LTP) and depression (LTD) of excitatory synapse strength require the Ca/calmodulin (CaM)-dependent protein kinase II (CaMKII) and its autonomous activity generated by Thr-286 autophosphorylation. Additionally, LTP and...
9.
Woolfrey K, Srivastava D
Neural Plast
. 2016 Mar;
2016:3025948.
PMID: 26989514
Structural plasticity of excitatory synapses is a vital component of neuronal development, synaptic plasticity, and behaviour. Abnormal development or regulation of excitatory synapses has also been strongly implicated in many...
10.
Woolfrey K, DellAcqua M
J Biol Chem
. 2015 Oct;
290(48):28604-12.
PMID: 26453308
A central theme in nervous system function is equilibrium: synaptic strengths wax and wane, neuronal firing rates adjust up and down, and neural circuits balance excitation with inhibition. This push/pull...