Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2015 Oct 11

PMID 26453308

Citations 70

Authors

Kevin M Woolfrey

Mark L DellAcqua

Affiliations

Soon will be listed here.

Abstract

A central theme in nervous system function is equilibrium: synaptic strengths wax and wane, neuronal firing rates adjust up and down, and neural circuits balance excitation with inhibition. This push/pull regulatory theme carries through to the molecular level at excitatory synapses, where protein function is controlled through phosphorylation and dephosphorylation by kinases and phosphatases. However, these opposing enzymatic activities are only part of the equation as scaffolding interactions and assembly of multi-protein complexes are further required for efficient, localized synaptic signaling. This review will focus on coordination of postsynaptic serine/threonine kinase and phosphatase signaling by scaffold proteins during synaptic plasticity.

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