Christopher W Leonard
Overview
Explore the profile of Christopher W Leonard including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
941
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Recent Articles
1.
Rice G, Leonard C, Weeks K
RNA
. 2014 Apr;
20(6):846-54.
PMID: 24742934
RNA secondary structure modeling is a challenging problem, and recent successes have raised the standards for accuracy, consistency, and tractability. Large increases in accuracy have been achieved by including data...
2.
Hajdin C, Bellaousov S, Huggins W, Leonard C, Mathews D, Weeks K
Proc Natl Acad Sci U S A
. 2013 Mar;
110(14):5498-503.
PMID: 23503844
A pseudoknot forms in an RNA when nucleotides in a loop pair with a region outside the helices that close the loop. Pseudoknots occur relatively rarely in RNA but are...
3.
Leonard C, Hajdin C, Karabiber F, Mathews D, Favorov O, Dokholyan N, et al.
Biochemistry
. 2013 Jan;
52(4):588-95.
PMID: 23316814
Accurate RNA structure modeling is an important, incompletely solved, challenge. Single-nucleotide resolution SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) yields an experimental measurement of local nucleotide flexibility that can...
4.
Gherghe C, Lombo T, Leonard C, Datta S, Bess Jr J, Gorelick R, et al.
Proc Natl Acad Sci U S A
. 2010 Oct;
107(45):19248-53.
PMID: 20974908
All retroviral genomic RNAs contain a cis-acting packaging signal by which dimeric genomes are selectively packaged into nascent virions. However, it is not understood how Gag (the viral structural protein)...
5.
Gherghe C, Leonard C, Gorelick R, Weeks K
J Virol
. 2009 Nov;
84(2):898-906.
PMID: 19889760
Retroviral genomes are dimeric, comprised of two sense-strand RNAs linked at their 5' ends by noncovalent base pairing and tertiary interactions. Viral maturation involves large-scale morphological changes in viral proteins...
6.
Watts J, Dang K, Gorelick R, Leonard C, Bess Jr J, Swanstrom R, et al.
Nature
. 2009 Aug;
460(7256):711-6.
PMID: 19661910
Single-stranded RNA viruses encompass broad classes of infectious agents and cause the common cold, cancer, AIDS and other serious health threats. Viral replication is regulated at many levels, including the...
7.
Gherghe C, Leonard C, Ding F, Dokholyan N, Weeks K
J Am Chem Soc
. 2009 Feb;
131(7):2541-6.
PMID: 19193004
The difficulty of analyzing higher order RNA structure, especially for folding intermediates and for RNAs whose functions require domains that are conformationally flexible, emphasizes the need for new approaches for...
8.
Maity T, Leonard C, Rose M, Fried H, Weeks K
Biochemistry
. 2006 Dec;
45(50):14955-64.
PMID: 17154533
Many ribonucleoprotein complexes assemble stepwise in distinct cellular compartments, a process that usually involves bidirectional transport of both RNA and proteins between the nucleus and cytoplasm. The biological rationale for...
9.
Longo A, Leonard C, Bassi G, Berndt D, Krahn J, Hall T, et al.
Nat Struct Mol Biol
. 2005 Aug;
12(9):779-87.
PMID: 16116439
LAGLIDADG endonucleases bind across adjacent major grooves via a saddle-shaped surface and catalyze DNA cleavage. Some LAGLIDADG proteins, called maturases, facilitate splicing by group I introns, raising the issue of...