Kevin M Magnaye
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Explore the profile of Kevin M Magnaye including associated specialties, affiliations and a list of published articles.
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13
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209
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Recent Articles
1.
Claytor J, Lin D, Magnaye K, Guerrero Y, Langelier C, Lynch S, et al.
Dig Dis Sci
. 2025 Jan;
PMID: 39804518
Background: Pouchitis is common among patients with ulcerative colitis (UC) who have had colectomy with ileal pouch-anal anastomosis. Antibiotics are first-line therapy for pouch inflammation, increasing the potential for gut...
2.
Zhang B, Magnaye K, Stryker E, Moltzau-Anderson J, Porsche C, Hertz S, et al.
Sci Rep
. 2024 Aug;
14(1):18558.
PMID: 39122767
Fecal microbial transplantation (FMT) offers promise for treating ulcerative colitis (UC), though the mechanisms underlying treatment failure are unknown. This study harnessed longitudinally collected colonic biopsies (n = 38) and...
3.
Lin D, Magnaye K, Porsche C, Levan S, Rackaityte E, Ozcam M, et al.
J Immunol Res
. 2024 Jul;
2024:2506586.
PMID: 38974097
Elevated infant fecal concentrations of the bacterial-derived lipid 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) increase the risk for childhood atopy and asthma. However, the mechanisms by which this lipid contributes to disease development...
4.
Washington 3rd C, Dapas M, Biddanda A, Magnaye K, Aneas I, Helling B, et al.
Genome Med
. 2022 Sep;
14(1):112.
PMID: 36175932
Background: Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. Methods: We tested for association with...
5.
Magnaye K, Clay S, Nicodemus-Johnson J, Naughton K, Huffman J, Altman M, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2116467119.
PMID: 35666868
Maternal asthma (MA) is among the most consistent risk factors for asthma in children. Possible mechanisms for this observation are epigenetic modifications in utero that have lasting effects on developmental...
6.
Aneas I, Decker D, Howard C, Sobreira D, Sakabe N, Blaine K, et al.
Nat Commun
. 2021 Oct;
12(1):6115.
PMID: 34675193
Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region within the GWAS-defined segment that acts...
7.
Magnaye K, Lynch S
Immunity
. 2021 May;
54(5):856-858.
PMID: 33979584
Intestinal microbiome perturbation characterizes Crohn's disease (CD), though specific contributors to pathophysiology remain elusive. In a recent issue of Science, Jain et al. show that Debaryomyces hansenii impairs intestinal healing...
8.
Magnaye K, Naughton K, Huffman J, Hogarth D, Naureckas E, White S, et al.
Eur Respir J
. 2021 Jan;
58(1).
PMID: 33446603
Background: Asthma is a chronic lung disease characterised by persistent airway inflammation. Altered microRNA (miRNA)-mediated gene silencing in bronchial epithelial cells (BECs) has been reported in asthma, yet adenosine deaminase...
9.
Stein M, Conery M, Magnaye K, Clay S, Billstrand C, Nicolae R, et al.
Sci Rep
. 2021 Jan;
11(1):1107.
PMID: 33441806
Sex-specific differences in prevalence are well documented for many common, complex diseases, especially for immune-mediated diseases, yet the precise mechanisms through which factors associated with biological sex exert their effects...
10.
Ober C, McKennan C, Magnaye K, Altman M, Washington 3rd C, Stanhope C, et al.
Lancet Respir Med
. 2020 May;
8(5):482-492.
PMID: 32380068
Background: African ancestry is associated with a higher prevalence and greater severity of asthma than European ancestries, yet genetic studies of the most common locus associated with childhood-onset asthma, 17q12-21,...