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Kevin J McHugh

Explore the profile of Kevin J McHugh including associated specialties, affiliations and a list of published articles. Areas
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Articles 63
Citations 1423
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Recent Articles
1.
Dixit D, Graf T, McHugh K, Lillehoj P
Microsyst Nanoeng . 2025 Feb; 11(1):36. PMID: 40016189
The quantification of immune cell subpopulations in blood is important for the diagnosis, prognosis and management of various diseases and medical conditions. Flow cytometry is currently the gold standard technique...
2.
Saenz G, Pogostin B, Cole C, Agrawal A, Chew-Martinez D, Dubackic M, et al.
Biomacromolecules . 2025 Jan; 26(1):490-502. PMID: 39801309
In this work, we investigate the pH-responsive behavior of multidomain peptide (MDP) hydrogels containing histidine. Small-angle X-ray scattering confirmed that MDP nanofibers sequester nonpolar residues into a hydrophobic core surrounded...
3.
Bice M, Yu M, Ortega V, Hsu C, McHugh K
Drug Deliv Transl Res . 2024 Dec; PMID: 39702689
Poly(glycerol sebacate) (PGS) is a biodegradable, elastomeric polymer that has been explored for applications including tissue engineering, drug delivery, and wound repair. Despite its promise, its biomedical utility is limited...
4.
Euliano E, Agrawal A, Yu M, Graf T, Henrich E, Kunkel A, et al.
Bioeng Transl Med . 2024 Nov; 9(6):e10705. PMID: 39545089
Lymph node (LN)-resident dendritic cells (DCs) are a promising target for vaccination given their professional antigen-presenting capabilities and proximity to a high concentration of immune cells. Direct intra-LN injection has...
5.
Agrawal A, Euliano E, Pogostin B, Yu M, Swain J, Hartgerink J, et al.
Cell Mol Bioeng . 2024 Nov; 17(5):441-451. PMID: 39513010
Introduction: Multidomain peptides (MDPs) are amino acid sequences that self-assemble to form supramolecular hydrogels under physiological conditions that have shown promise for a number of biomedical applications. K(SL)K ("K"), a...
6.
Duray A, Miller L, Dresden B, Rago F, Antos D, McHugh K, et al.
J Immunol . 2024 Nov; 213(12):1834-1843. PMID: 39485002
Every year millions of people are infected with influenza, which can be complicated by secondary bacterial pneumonia. One factor that may contribute to increased susceptibility to secondary bacterial infection is...
7.
Euliano E, Pogostin B, Agrawal A, Yu M, Baryakova T, Graf T, et al.
Adv Healthc Mater . 2024 Oct; 14(3):e2402958. PMID: 39460390
Toll-like receptors (TLRs) recognize pathogen- and damage-associated molecular patterns and, in turn, trigger the release of cytokines and other immunostimulatory molecules. As a result, TLR agonists are increasingly being investigated...
8.
Jiao M, Li X, Liu H, Cai P, Yang X, McHugh K, et al.
ACS Nano . 2024 Jul; 18(29):19038-19053. PMID: 38979966
Surgical intervention is the most common first-line treatment for severe traumatic brain injuries (TBIs) associated with high intracranial pressure, while the complexity of these surgical procedures often results in complications....
9.
Pogostin B, Wu S, Swierczynski M, Pennington C, Li S, Vohidova D, et al.
bioRxiv . 2024 Jun; PMID: 38826442
Maintaining safe and potent pharmaceutical drug levels is often challenging. Multidomain peptides (MDPs) assemble into supramolecular hydrogels with a well-defined, highly porous nanostructure that makes them attractive for drug delivery,...
10.
Euliano E, Pogostin B, Agrawal A, Yu M, Baryakova T, Graf T, et al.
bioRxiv . 2024 Mar; PMID: 38496534
Table Of Contents: Activation of toll-like receptors (TLRs) stimulates a signaling cascade to induce an immune response. A TLR7 agonist was conjugated to an injectable peptide hydrogel, which was then...