Kevin DeBoyace
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Explore the profile of Kevin DeBoyace including associated specialties, affiliations and a list of published articles.
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11
Citations
52
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Recent Articles
1.
Munjal B, DeBoyace K, Cao F, Krzyzaniak J, Arora K, Suryanarayanan R
Mol Pharm
. 2024 Aug;
21(10):5150-5158.
PMID: 39137015
Our previous work (Mol Pharm, 20 (2023) 3427) showed that crystalline excipients, specifically anhydrous dibasic calcium phosphate (DCPA), facilitated the dehydration of carbamazepine dihydrate (CBZDH) and the formation of an...
2.
DeBoyace K, Bookwala M, Zhou D, Buckner I, Wildfong P
Mol Pharm
. 2024 Jan;
21(2):770-780.
PMID: 38181202
The 3 molecular descriptor (R-GETAWAY third-order autocorrelation index weighted by the atomic mass) has previously been shown to encode molecular attributes that appear to be physically and chemically relevant to...
3.
Munjal B, DeBoyace K, Cao F, Krzyzaniak J, Arora K, Suryanarayanan R
Mol Pharm
. 2023 May;
20(7):3427-3437.
PMID: 37232571
In recent years, continuous tablet manufacturing technology has been used to obtain regulatory approval of several new drug products. While a significant fraction of active pharmaceutical ingredients exists as hydrates...
4.
DeBoyace K, Bookwala M, Buckner I, Zhou D, Wildfong P
Mol Pharm
. 2021 Dec;
19(1):303-317.
PMID: 34932358
A molecular descriptor known as R3m (the R-GETAWAY ) was previously identified as capable of grouping members of an 18-compound library of organic molecules that successfully formed amorphous solid dispersions...
5.
Crystal structure of -butyl 4-[4-(4-fluoro-phen-yl)-2-methyl-but-3-yn-2-yl]piperazine-1-carboxyl-ate
Gumireddy A, DeBoyace K, Rupprecht A, Gupta M, Patel S, Flaherty P, et al.
Acta Crystallogr E Crystallogr Commun
. 2021 May;
77(Pt 4):360-365.
PMID: 33936758
The title sterically congested piperazine derivative, CHFNO, was prepared using a modified Bruylants approach. A search of the Cambridge Structural Database identified 51 compounds possessing an butyl piperazine substructure. Of...
6.
Bookwala M, DeBoyace K, Buckner I, Wildfong P
AAPS PharmSciTech
. 2020 Feb;
21(3):96.
PMID: 32103355
The true density of an amorphous solid is an important parameter for studying and modeling materials behavior. Experimental measurements of density using helium pycnometry are standard but may be prevented...
7.
DeBoyace K, Zdaniewski C, Wildfong P
J Pharm Biomed Anal
. 2017 Dec;
150:43-50.
PMID: 29216584
Differential scanning calorimetry (DSC) is a commonly employed analytical technique for the analysis and characterization of amorphous solid dispersions. However, steps typical of standard temperature programs can alter the material...
8.
DeBoyace K, Buckner I, Gong Y, Ju T, Wildfong P
J Pharm Sci
. 2017 Oct;
107(1):334-343.
PMID: 29031977
The expansion of a novel in silico model for the prediction of the dispersability of 18 model compounds with polyvinylpyrrolidone-vinyl acetate copolymer is described. The molecular descriptor R3m (atomic mass...
9.
DeBoyace K, Wildfong P
J Pharm Sci
. 2017 Apr;
107(1):57-74.
PMID: 28389266
Amorphous solid dispersion (ASD) formulation development is frequently difficult owing to the inherent physical instability of the amorphous form, and limited understanding of the physical and chemical interactions that translate...
10.
Butz J, de la Cruz L, DiTonno J, DeBoyace K, Ewing G, Donovan B, et al.
J Pharm Biomed Anal
. 2011 Jan;
54(5):1013-9.
PMID: 21232901
The purpose of this research was to demonstrate the utility of Raman spectroscopy for process analysis of a suspension metered dose inhaler manufacturing process. Chemometric models were constructed for the...