Bhushan Munjal
Overview
Explore the profile of Bhushan Munjal including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
109
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Recent Articles
1.
Zeng C, Li J, Shi J, Bates S, Munjal B, Suryanarayanan R
Mol Pharm
. 2025 Feb;
22(3):1686-1696.
PMID: 39943706
Mannitol is widely employed as a bulking agent in lyophilized formulations. Our goal was to evaluate the role of noncrystallizing cosolutes in inhibiting mannitol crystallization and preventing the formation of...
2.
Munjal B, DeBoyace K, Cao F, Krzyzaniak J, Arora K, Suryanarayanan R
Mol Pharm
. 2024 Aug;
21(10):5150-5158.
PMID: 39137015
Our previous work (Mol Pharm, 20 (2023) 3427) showed that crystalline excipients, specifically anhydrous dibasic calcium phosphate (DCPA), facilitated the dehydration of carbamazepine dihydrate (CBZDH) and the formation of an...
3.
Li J, Munjal B, Zeng C, Suryanarayanan R
Mol Pharm
. 2024 Mar;
21(5):2555-2564.
PMID: 38551918
Poloxamer 188 (P188) was hypothesized to be a dual functional excipient, (i) a stabilizer in frozen solution to prevent ice-surface-induced protein destabilization and (ii) a bulking agent to provide elegant...
4.
Munjal B, DeBoyace K, Cao F, Krzyzaniak J, Arora K, Suryanarayanan R
Mol Pharm
. 2023 May;
20(7):3427-3437.
PMID: 37232571
In recent years, continuous tablet manufacturing technology has been used to obtain regulatory approval of several new drug products. While a significant fraction of active pharmaceutical ingredients exists as hydrates...
5.
Thakral S, Sonje J, Munjal B, Bhatnagar B, Suryanarayanan R
J Pharm Sci
. 2022 Aug;
112(1):19-35.
PMID: 36030846
The review summarizes the current state of knowledge of mannitol as an excipient in lyophilized injectable small and large molecule formulations. When compared with glycine, the physicochemical properties of mannitol...
6.
Munjal B, Patel S, Suryanarayanan R
Int J Pharm
. 2022 Mar;
619:121694.
PMID: 35331829
While arginine hydrochloride (ArgHCl) has emerged as a potential stabilizer of protein drugs in liquid formulations, the purpose of this manuscript was to evaluate its stabilization potential in frozen solutions....
7.
Thakral S, Sonje J, Munjal B, Suryanarayanan R
Adv Drug Deliv Rev
. 2021 Mar;
173:1-19.
PMID: 33741437
This review aims to provide an overview of the current knowledge on protein stabilization during freezing and freeze-drying in relation to stress conditions commonly encountered during these processes. The traditional...
8.
Thorat A, Munjal B, Geders T, Suryanarayanan R
J Control Release
. 2020 Apr;
323:591-599.
PMID: 32335158
The aggregation behavior of two model proteins- i) bovine serum albumin (BSA) and ii) β-galactosidase (β-gal), was investigated by micro-flow imaging (MFI) during freeze-thaw cycling in phosphate buffered solutions. The...
9.
Munjal B, Zode S, Bansal A
J Pharm Sci
. 2018 Oct;
108(3):1195-1202.
PMID: 30352215
The purpose of this study was to investigate the phase behavior of cyclophosphamide (CPA) during various stages of lyophilization, with special emphasis on obtaining crystalline CPA monohydrate (CPA-MH) in the...
10.
Dalsania S, Sharma J, Munjal B, Bansal A
Pharm Res
. 2018 Jan;
35(2):29.
PMID: 29368174
Purpose: Drug-polymer miscibility has been proposed to play a critical role in physical stability of amorphous solid dispersions (ASDs). The purpose of the current work was to investigate the role...