Kestutis Timinskas
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Explore the profile of Kestutis Timinskas including associated specialties, affiliations and a list of published articles.
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7
Citations
118
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Recent Articles
1.
Timinskas K, Timinskas A, Venclovas C
Comput Struct Biotechnol J
. 2025 Feb;
27:401-410.
PMID: 39906160
Translesion DNA synthesis (TLS) is typically performed by inherently error-prone Y-family DNA polymerases. Extensively studied Pol V mutasome, composed of UmuC, an UmuD' dimer and RecA is an example of...
2.
Santos J, Timinskas K, Ramudzuli A, Lamers M, Venclovas C, Warner D, et al.
J Biol Chem
. 2024 Dec;
301(2):108108.
PMID: 39706264
The mycobacterial mutasome-comprising ImuA', ImuB, and DnaE2-has been implicated in DNA damage-induced mutagenesis in Mycobacterium tuberculosis. ImuB, which is predicted to enable mutasome function via its interaction with the β...
3.
Santos J, Timinskas K, Lamers M, Venclovas C, Warner D, Gessner S
bioRxiv
. 2023 Apr;
PMID: 37034714
The mycobacterial mutasome - minimally comprising ImuA', ImuB, and DnaE2 proteins - has been implicated in DNA damage-induced mutagenesis in . ImuB, predicted to enable mutasome function via its interaction...
4.
Zaremba M, Dakineviciene D, Golovinas E, Zagorskaite E, Stankunas E, Lopatina A, et al.
Nat Microbiol
. 2022 Oct;
7(11):1857-1869.
PMID: 36192537
Argonaute (Ago) proteins are found in all three domains of life. The so-called long Agos are composed of four major domains (N, PAZ, MID and PIWI) and contribute to RNA...
5.
Laan M, Kasak L, Timinskas K, Grigorova M, Venclovas C, Renaux A, et al.
Clin Endocrinol (Oxf)
. 2020 Dec;
94(4):656-666.
PMID: 33296094
Objective: The study aimed to identify the genetic basis of partial gonadal dysgenesis (PGD) in a non-consanguineous family from Estonia. Patients: Cousins P (proband) 1 (12 years; 46,XY) and P2...
6.
Timinskas K, Venclovas C
Nucleic Acids Res
. 2019 Mar;
47(9):4393-4405.
PMID: 30916324
Bacterial Y-family DNA polymerases are usually classified into DinB (Pol IV), UmuC (the catalytic subunit of Pol V) and ImuB, a catalytically dead essential component of the ImuA-ImuB-DnaE2 mutasome. However,...
7.
Timinskas K, Balvociute M, Timinskas A, Venclovas C
Nucleic Acids Res
. 2013 Oct;
42(3):1393-413.
PMID: 24106089
The analysis of ∼ 2000 bacterial genomes revealed that they all, without a single exception, encode one or more DNA polymerase III α-subunit (PolIIIα) homologs. Classified into C-family of DNA...
8.
Timinskas K, Venclovas C
FEBS J
. 2011 Jul;
278(17):3109-18.
PMID: 21740522
PolC is one of two essential replicative DNA polymerases in Bacillus subtilis and other Gram-positive bacteria. The 3D structure of PolC has recently been solved, yet it lacks the N-terminal...