Kerstin Schaefer
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Explore the profile of Kerstin Schaefer including associated specialties, affiliations and a list of published articles.
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11
Citations
86
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Recent Articles
1.
Trenkenschuh E, Blattner S, Hirsh D, Hoffmann R, Luebbert C, Schaefer K
Mol Pharm
. 2024 Feb;
21(3):1309-1320.
PMID: 38345459
Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable from an economic and ecological perspective but also limited to thermostable active pharmaceutical ingredients (APIs). A potential technology shift...
2.
Raines K, Agarwal P, Augustijns P, Alayoubi A, Attia L, Bauer-Brandl A, et al.
AAPS J
. 2023 Nov;
25(6):103.
PMID: 37936002
The in-person workshop "Drug Dissolution in Oral Drug Absorption" was held on May 23-24, 2023, in Baltimore, MD, USA. The workshop was organized into lectures and breakout sessions. Three common...
3.
Gierke H, Mouchantat S, Berg S, Grimm M, Hadlich S, Kromrey M, et al.
Pharmaceutics
. 2023 Mar;
15(3).
PMID: 36986751
Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after...
4.
Gierke H, Schaefer K, Gerlich L, Willmann A, Bialetzki V, Boeck G, et al.
Pharmaceutics
. 2022 Dec;
14(12).
PMID: 36559103
The formation of pharmacobezoars from suspensions of spray-dried amorphous solid dispersions (SD-ASDs) of new chemical entities (NCEs) and hydroxypropyl methylcellulose acetate succinate (HPMC-AS) represents a non-compound related adverse effect in...
5.
Morak M, Pineda M, Martins A, Gaildrat P, Tubeuf H, Drouet A, et al.
Eur J Hum Genet
. 2022 Jun;
30(9):1051-1059.
PMID: 35676339
Over 20% of the DNA mismatch repair (MMR) germline variants in suspected Lynch syndrome patients are classified as variants of uncertain significance (VUS). Well-established functional assays are pivotal for assessing...
6.
Arif N, Zinnhardt M, NyamayAntu A, Teber D, Bruckner R, Schaefer K, et al.
EMBO J
. 2021 Feb;
40(9):e106113.
PMID: 33604918
Leukocyte extravasation is an essential step during the immune response and requires the destabilization of endothelial junctions. We have shown previously that this process depends in vivo on the dephosphorylation...
7.
Schilderink R, Protopappa M, Fleth-James J, Vertzoni M, Schaefer K, Havenaar R, et al.
Eur J Pharm Biopharm
. 2020 Feb;
149:154-162.
PMID: 32057905
We evaluated the usefulness of quality control dissolution data collected with compendial Apparatus I and II, biorelevant dissolution data collected with compendial apparatus IV, and bioaccessibility data collected with the...
8.
Morak M, Schaefer K, Steinke-Lange V, Koehler U, Keinath S, Massdorf T, et al.
Eur J Hum Genet
. 2019 Jul;
27(12):1808-1820.
PMID: 31332305
In pathogenicity assessment, RNA-based analyses are important for the correct classification of variants, and require gene-specific cut-offs for allelic representation and alternative/aberrant splicing. Beside this, the diagnostic yield of RNA-based...
9.
Simonis G, Steiding K, Schaefer K, Rauwolf T, Strasser R
Clin Res Cardiol
. 2012 Jun;
101(12):955-62.
PMID: 22729756
Background: Continuous lateral rotation ["Kinetic therapy" (KT)] has been shown to reduce complications and to shorten hospital stay in trauma patients. Data in non-surgical patients is inconclusive. Retrospective data suggest...
10.
Buehren K, Konrad K, Schaefer K, Kratzsch J, Kahraman-Lanzerath B, Lente C, et al.
J Neural Transm (Vienna)
. 2011 Jan;
118(6):963-8.
PMID: 21207075
A growing body of evidence indicates that hormones play an important role in learning and memory functions as well as in mood modulation. During the acute stage of anorexia nervosa...