Kerrin Hansen
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Explore the profile of Kerrin Hansen including associated specialties, affiliations and a list of published articles.
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9
Citations
55
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Recent Articles
1.
Hansen K, Peters K, Burkert C, Brose E, Calvisi D, Ehricke K, et al.
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39518998
Glycogen-storing so-called clear cell kidney tubules (CCTs), precursor lesions of renal cell carcinoma, have been described in diabetic rats and in humans. The lesions show upregulation of the Akt/mTOR-pathway and...
2.
Nerlich C, Tiedjens F, Hertel R, Henke B, Hauer S, Panitzsch L, et al.
J Med Chem
. 2024 Oct;
67(20):18368-18383.
PMID: 39361938
Inhibition of the lactate transporter PfFNT is a valid novel mode of action against malaria parasites. Current pyridine-substituted pentafluoro-3-hydroxy-pent-2-en-1-ones act as substrate analogs with submicromolar EC in vitro, and >99.7%...
3.
Jakobowska I, Becker F, Minguzzi S, Hansen K, Henke B, Epalle N, et al.
Pharmaceuticals (Basel)
. 2021 Aug;
14(8).
PMID: 34451854
Blocking lactate export in the parasitic protozoan is a novel strategy to combat malaria. We discovered small drug-like molecules that inhibit the sole plasmodial lactate transporter, PfFNT, and kill parasites...
4.
Heinrich T, Seenisamy J, Becker F, Blume B, Bomke J, Dietz M, et al.
J Med Chem
. 2019 Nov;
62(24):11119-11134.
PMID: 31725285
The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the lead compound suffered from enterohepatic circulation, preventing further development. Nevertheless,...
5.
Crochiere M, Hannus S, Hansen K, Becker F, Baloglu E, Lee M, et al.
Oncotarget
. 2018 Jan;
8(66):110503-110516.
PMID: 29299164
XPO1 (exportin 1) is the main nuclear export protein with over 200 different protein cargos. XPO1 is overexpressed in tumor cells and high levels are correlated with poor prognosis. Selective...
6.
Antoine T, Ott D, Ebell K, Hansen K, Henry L, Becker F, et al.
Anal Biochem
. 2016 Mar;
502:24-35.
PMID: 26954998
G protein-coupled receptors (GPCRs) mediate many important physiological functions and are considered as one of the most successful therapeutic target classes for a wide spectrum of diseases. Drug discovery projects...
7.
Jakob L, Treiber T, Treiber N, Gust A, Kramm K, Hansen K, et al.
RNA
. 2016 Jan;
22(3):383-96.
PMID: 26769856
In the microRNA (miRNA) pathway, Dicer processes precursors to mature miRNAs. For efficient processing, double-stranded RNA-binding proteins support Dicer proteins. In flies, Loquacious (Loqs) interacts with Dicer1 (dmDcr1) to facilitate...
8.
Glauner H, Ruttekolk I, Hansen K, Steemers B, Chung Y, Becker F, et al.
Br J Pharmacol
. 2010 Jul;
160(4):958-70.
PMID: 20590591
Background And Purpose: In vitro assays that determine activities of drug candidates with isolated targets have only limited predictive value for activities in cellular assays. Poor membrane permeability and off-target...
9.
Hansen K, Ruttekolk I, Glauner H, Becker F, Brock R, Hannus S
Mol Immunol
. 2009 Aug;
46(16):3269-77.
PMID: 19699529
Antibodies of the IgG4 subclass, directed against cell surface antigens have received attention as therapeutic molecules due to their poor induction of the complement system. The MHC class II-directed IgG4...