Keri Dame
Overview
Explore the profile of Keri Dame including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
119
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Recent Articles
1.
Arefin A, Mendoza M, Dame K, Garcia M, Strauss D, Ribeiro A
Front Pharmacol
. 2023 Jul;
14:1212092.
PMID: 37469866
Engineered heart tissues (EHTs) are three-dimensional culture platforms with cardiomyocytes differentiated from human pluripotent stem cells (hPSCs) and were designed for assaying cardiac contractility. For drug development applications, EHTs must...
2.
Rubiano A, Indapurkar A, Yokosawa R, Miedzik A, Rosenzweig B, Arefin A, et al.
Clin Transl Sci
. 2020 Dec;
14(3):1049-1061.
PMID: 33382907
Liver microphysiological systems (MPSs) are promising models for predicting hepatic drug effects. Yet, after a decade since their introduction, MPSs are not routinely used in drug development due to lack...
3.
Microengineered systems with iPSC-derived cardiac and hepatic cells to evaluate drug adverse effects
Dame K, Ribeiro A
Exp Biol Med (Maywood)
. 2020 Sep;
246(3):317-331.
PMID: 32938227
Hepatic and cardiac drug adverse effects are among the leading causes of attrition in drug development programs, in part due to predictive failures of current animal or models. Hepatocytes and...
4.
Maddah M, Mandegar M, Dame K, Grafton F, Loewke K, Ribeiro A
J Pharmacol Toxicol Methods
. 2020 Jul;
105:106895.
PMID: 32629158
Cardiac and hepatic toxicity result from induced disruption of the functioning of cardiomyocytes and hepatocytes, respectively, which is tightly related to the organization of their subcellular structures. Cellular structure can...
5.
Ikonomou L, Herriges M, Lewandowski S, Marsland 3rd R, Villacorta-Martin C, Caballero I, et al.
Nat Commun
. 2020 Feb;
11(1):635.
PMID: 32005814
Multipotent Nkx2-1-positive lung epithelial primordial progenitors of the foregut endoderm are thought to be the developmental precursors to all adult lung epithelial lineages. However, little is known about the global...
6.
Dame K, Cincotta S, Lang A, Sanghrajka R, Zhang L, Choi J, et al.
Stem Cell Reports
. 2017 Feb;
8(2):216-225.
PMID: 28162994
The clinical importance of anterior foregut endoderm (AFE) derivatives, such as thyrocytes, has led to intense research efforts for their derivation through directed differentiation of pluripotent stem cells (PSCs). Here,...