Keren I Hilgendorf
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Explore the profile of Keren I Hilgendorf including associated specialties, affiliations and a list of published articles.
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12
Citations
427
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Recent Articles
1.
Vieira R, Sanchez S, Arumugam M, Mower P, Curtin M, Gallop M, et al.
bioRxiv
. 2025 Feb;
PMID: 39990404
Obesity is an established risk factor for breast cancer (BC), yet the specific mechanisms driving this association remain unclear. Dysregulated lipid metabolism has emerged as a key factor in cancer...
2.
Curtin M, Jackson A, Hilgendorf K
J Vis Exp
. 2025 Feb;
(215).
PMID: 39927672
Adipose tissue is primarily composed of mature, lipid-laden adipocytes by volume. These postmitotic cells play a critical role in energy storage and mobilization, thermoregulation, and the secretion of endocrine factors....
3.
Verma S, Giagnocavo S, Curtin M, Arumugam M, Osburn-Staker S, Wang G, et al.
Cancer Res Commun
. 2024 Jun;
4(7):1655-1666.
PMID: 38888911
Significance: Functional screening of breast cancer secretomes revealed that triple-negative breast cancer promotes fibrosis in the adipose tissue microenvironment by secreting zinc-alpha-2-glycoprotein and promoting the transdifferentiation of adipocyte stem cells...
4.
Verma S, Giagnocavo S, Curtin M, Arumugam M, Osburn-Staker S, Wang G, et al.
bioRxiv
. 2024 Mar;
PMID: 38496643
Obesity is a predisposition factor for breast cancer, suggesting a localized, reciprocal interaction between breast cancer cells and the surrounding mammary white adipose tissue. To investigate how breast cancer cells...
5.
Hilgendorf K, Myers B, Reiter J
Nat Rev Mol Cell Biol
. 2024 Feb;
25(7):555-573.
PMID: 38366037
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal...
6.
Garritson J, Zhang J, Achenbach A, Ferhat M, Eich E, Stubben C, et al.
Commun Biol
. 2023 Jun;
6(1):638.
PMID: 37311809
Autocrine and paracrine signaling regulating adipogenesis in white adipose tissue remains largely unclear. Here we used single-cell RNA-sequencing (RNA-seq) and single nuclei RNA-sequencing (snRNA-seq) to identify markers of adipose progenitor...
7.
Scamfer S, Lee M, Hilgendorf K
Front Cell Dev Biol
. 2022 Dec;
10:1083372.
PMID: 36561368
The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy...
8.
Porpiglia E, Mai T, Kraft P, Holbrook C, de Morree A, Gonzalez V, et al.
Cell Stem Cell
. 2022 Nov;
29(12):1653-1668.e8.
PMID: 36384141
In aging, skeletal muscle strength and regenerative capacity decline, due in part to functional impairment of muscle stem cells (MuSCs), yet the underlying mechanisms remain elusive. Here, we capitalize on...
9.
Palla A, Hilgendorf K, Yang A, Kerr J, Hinken A, Demeter J, et al.
Nat Commun
. 2022 Mar;
13(1):1439.
PMID: 35301320
During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases, diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs to regenerate is...
10.
Hilgendorf K
Front Physiol
. 2021 Nov;
12:769367.
PMID: 34759842
The primary cilium is a microtubule-based cellular protrusion found on most mammalian cell types in diverse tissues. It functions as a cellular antenna to sense and transduce a broad range...