Zinc-alpha-2-glycoprotein Secreted by Triple-Negative Breast Cancer Promotes Peritumoral Fibrosis

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2024 Jun 18

PMID 38888911

Authors

Surbhi Verma

Stephanie D Giagnocavo

Meghan C Curtin

Menusha Arumugam

Sandra M Osburn-Staker

Guoying Wang

Aaron Atkinson

David A Nix

David H Lum

James E Cox

Keren I Hilgendorf

Affiliations

Soon will be listed here.

Abstract

Significance: Functional screening of breast cancer secretomes revealed that triple-negative breast cancer promotes fibrosis in the adipose tissue microenvironment by secreting zinc-alpha-2-glycoprotein and promoting the transdifferentiation of adipocyte stem cells into myofibroblasts.

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PMID: 39711976 PMC: 11662974. DOI: 10.1515/biol-2022-1007.

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