Kenneth Witwer
Overview
Explore the profile of Kenneth Witwer including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
804
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Recent Articles
1.
Tordoff E, Allen J, Elgart K, Elsherbini A, Kalia V, Wu H, et al.
J Extracell Vesicles
. 2024 Nov;
13(11):e70007.
PMID: 39498678
Small membranous extracellular vesicles (EV) incorporate proteins and nucleic acids from the parent cell. Proteins exposed on EV surface are dictated by cellular origin and biogenesis pathway. To better understand...
2.
Ogrodnik M, Carlos Acosta J, Adams P, dAdda di Fagagna F, Baker D, Bishop C, et al.
Cell
. 2024 Aug;
187(16):4150-4175.
PMID: 39121846
Cellular senescence is a cell fate triggered in response to stress and is characterized by stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging from tissue...
3.
Shekari F, Alibhai F, Baharvand H, Borger V, Bruno S, Davies O, et al.
J Extracell Biol
. 2024 Jun;
2(10):e115.
PMID: 38939735
Cell culture-conditioned medium (CCM) is a valuable source of extracellular vesicles (EVs) for basic scientific, therapeutic and diagnostic applications. Cell culturing parameters affect the biochemical composition, release and possibly the...
4.
Castellano M, Blanco V, Calzi M, Costa B, Witwer K, Hill M, et al.
bioRxiv
. 2024 May;
PMID: 38712104
The plasma membrane and the membrane of endosomal vesicles are considered physical barriers preventing extracellular RNA uptake. While naked RNA can be spontaneously internalized by certain cells types, functional delivery...
5.
Broad K, Walker S, Davidovich I, Witwer K, Talmon Y, Wolfram J
J Extracell Vesicles
. 2023 Feb;
12(2):e12309.
PMID: 36732941
Extracellular vesicles (EVs) are cell-released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies...
6.
Costa B, Calzi M, Castellano M, Blanco V, Cuevasanta E, Litvan I, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2216330120.
PMID: 36652478
Nonvesicular extracellular RNAs (nv-exRNAs) constitute the majority of the extracellular RNAome, but little is known about their stability, function, and potential use as disease biomarkers. Herein, we measured the stability...
7.
Tosar J, Cayota A, Witwer K
J Extracell Biol
. 2022 Oct;
1(6).
PMID: 36311878
Extracellular vesicles (EVs), including exosomes and microvesicles, are far from being the only RNA-containing extracellular particles (EPs). Recently, new 35 nm-sized EPs were discovered by asymmetric-flow field-flow fractionation and termed...
8.
Davidson S, Boulanger C, Aikawa E, Badimon L, Barile L, Binder C, et al.
Cardiovasc Res
. 2022 Mar;
119(1):45-63.
PMID: 35325061
Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from cells of the cardiovascular system, and are considered important mediators of intercellular and extracellular communications. Two...
9.
Avramopoulos D, Kapogiannis D, Leoutsakos J, Lyketsos C, Mahairaki V, Nowrangi M, et al.
Adv Exp Med Biol
. 2022 Jan;
1339:395-402.
PMID: 35023131
Precision medicine, also known as personalized medicine, is concerned with finding the right treatment for the right patient at the right time. It is a way of thinking focused on...
10.
Verweij F, Balaj L, Boulanger C, Carter D, Compeer E, DAngelo G, et al.
Nat Methods
. 2021 Aug;
18(9):1013-1026.
PMID: 34446922
Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every cell type. EVs have diverse biological activities, ranging from roles in development and homeostasis to cancer progression, which...