Kenneth W Young
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Explore the profile of Kenneth W Young including associated specialties, affiliations and a list of published articles.
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20
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1026
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Recent Articles
1.
Lal M, Young K, Andag U
Drug Discov Today
. 2015 Jun;
20(10):1228-34.
PMID: 26096184
The majority of chronic kidney disease (CKD) cases have their origin in the glomerulus, the microvascular unit of the nephron that serves as a filter tasked with forming primary urine....
2.
Agostini M, Tucci P, Steinert J, Shalom-Feuerstein R, Rouleau M, Aberdam D, et al.
Proc Natl Acad Sci U S A
. 2011 Dec;
108(52):21099-104.
PMID: 22160706
The p53 family member TAp73 is a transcription factor that plays a key role in many biological processes, including neuronal development. In particular, we have shown that p73 drives the...
3.
Lippi G, Steinert J, Marczylo E, DOro S, Fiore R, Forsythe I, et al.
J Cell Biol
. 2011 Sep;
194(6):889-904.
PMID: 21930776
Previous studies have demonstrated that microribonucleic acids (miRs) are key regulators of protein expression in the brain and modulate dendritic spine morphology and synaptic activity. To identify novel miRs involved...
4.
Attwood B, Bourgognon J, Patel S, Mucha M, Schiavon E, Skrzypiec A, et al.
Nature
. 2011 Apr;
473(7347):372-5.
PMID: 21508957
A minority of individuals experiencing traumatic events develop anxiety disorders. The reason for the lack of correspondence between the prevalence of exposure to psychological trauma and the development of anxiety...
5.
Ziviani E, Lippi G, Bano D, Munarriz E, Guiducci S, Zoli M, et al.
EMBO J
. 2010 Nov;
30(1):194-204.
PMID: 21113126
Nicotine, the major psychoactive component of cigarette smoke, modulates neuronal activity to produce Ca2+-dependent changes in gene transcription. However, the downstream targets that underlie the long-term effects of nicotine on...
6.
Young K, Pinon L, Dhiraj D, Twiddy D, MacFarlane M, Hickman J, et al.
Neuropharmacology
. 2010 Mar;
58(8):1258-67.
PMID: 20307556
Inhibition of pro-survival Bcl-2 family proteins by BH3-only proteins is a key initial step leading to apoptotic cell death. In neurons, investigating cell death pathways is often hampered by the...
7.
Young K, Pinon L, Bampton E, Nicotera P
J Biochem Mol Toxicol
. 2010 Mar;
24(5):335-41.
PMID: 20201108
Mitochondrial fragmentation is recognized to be an important event during the onset of apoptosis. In this current study, we have used single cell imaging to investigate the role of the...
8.
Carroll J, Hill D, Allen P, Young K, Miramontes E, Kramer M, et al.
Vector Borne Zoonotic Dis
. 2009 Aug;
9(4):407-16.
PMID: 19650735
From 1998-2002 twenty-five deer self-treatment devices (4-Posters), using 2% amitraz, were operated at three locations in Maryland to determine their effectiveness in controlling blacklegged ticks, Ixodes scapularis Say, and lone...
9.
Bellodi C, Lidonnici M, Hamilton A, Helgason G, Soliera A, Ronchetti M, et al.
J Clin Invest
. 2009 Apr;
119(5):1109-23.
PMID: 19363292
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance increases in...
10.
Butcher A, Torrecilla I, Young K, Kong K, Mistry S, Bottrill A, et al.
J Biol Chem
. 2009 Apr;
284(25):17147-17156.
PMID: 19332541
Changes in synaptic strength mediated by ionotropic glutamate N-methyl-D-asparate (NMDA) receptors is generally considered to be the molecular mechanism underlying memory and learning. NMDA receptors themselves are subject to regulation...