Kenneth R Pryde
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Explore the profile of Kenneth R Pryde including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
411
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0
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Recent Articles
1.
Hardy R, Chung I, Yu Y, Loh S, Morone N, Soleilhavoup C, et al.
Biol Direct
. 2023 Aug;
18(1):43.
PMID: 37528429
Antipsychotic drugs are the mainstay of treatment for schizophrenia and provide adjunct therapies for other prevalent psychiatric conditions, including bipolar disorder and major depressive disorder. However, they also induce debilitating...
2.
Trapotsi M, Mouchet E, Williams G, Monteverde T, Juhani K, Turkki R, et al.
ACS Chem Biol
. 2022 Jul;
17(7):1733-1744.
PMID: 35793809
PROteolysis TArgeting Chimeras (PROTACs) use the ubiquitin-proteasome system to degrade a protein of interest for therapeutic benefit. Advances made in targeted protein degradation technology have been remarkable, with several molecules...
3.
Stephenson Z, Harvey R, Pryde K, Mistry S, Hardy R, Serreli R, et al.
Elife
. 2020 May;
9.
PMID: 32432547
Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial toxins resulting...
4.
Pryde K, Smith H, Chau K, Schapira A
J Cell Biol
. 2016 Apr;
213(2):163-71.
PMID: 27091447
Mitochondrial fission is essential for the degradation of damaged mitochondria. It is currently unknown how the dynamin-related protein 1 (DRP1)-associated fission machinery is selectively targeted to segregate damaged mitochondria. We...
5.
Pryde K, Hirst J
J Biol Chem
. 2011 Mar;
286(20):18056-65.
PMID: 21393237
NADH:ubiquinone oxidoreductase (complex I) is a major source of reactive oxygen species in mitochondria and a contributor to cellular oxidative stress. In isolated complex I the reduced flavin is known...
6.
Hirst J, King M, Pryde K
Biochem Soc Trans
. 2008 Sep;
36(Pt 5):976-80.
PMID: 18793173
ROS (reactive oxygen species) are considered to be a major cause of cellular oxidative stress, linked to neuromuscular diseases and aging. Complex I (NADH:ubiquinone oxidoreductase) is one of the main...
7.
Mankouri J, Milward A, Pryde K, Warter L, Martin A, Harris M
J Gen Virol
. 2008 Jul;
89(Pt 8):1911-1920.
PMID: 18632962
GB virus B (GBV-B) is the closest relative to hepatitis C virus (HCV) with which it shares a common genome organization, however, unlike HCV in humans, it generally causes an...