Kenneth N Barton
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Explore the profile of Kenneth N Barton including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
394
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Recent Articles
1.
Nyati S, Stricker H, Barton K, Li P, Elshaikh M, Ali H, et al.
PLoS One
. 2023 Sep;
18(9):e0291315.
PMID: 37713401
In a phase I dose escalation and safety study (NCT02555397), a replication-competent oncolytic adenovirus expressing yCD, TK and hIL-12 (Ad5-yCD/mutTKSR39rep-hIL-12) was administered in 15 subjects with localized recurrent prostate cancer...
2.
Barton K, Siddiqui F, Pompa R, Freytag S, Khan G, Dobrosotskaya I, et al.
Mol Ther Oncolytics
. 2021 Feb;
20:94-104.
PMID: 33575474
The safety of oncolytic adenovirus-mediated suicide and interleukin-12 ( ) gene therapy was evaluated in metastatic pancreatic cancer patients. In this phase I study, a replication-competent adenovirus (Ad5-yCD/TK -hIL-12) expressing...
3.
Varma N, Barton K, Janic B, Shankar A, Iskander A, Ali M, et al.
World J Clin Oncol
. 2014 Jun;
4(4):91-101.
PMID: 24926429
Aim: To determine whether endothelial progenitor cells (EPCs) can be used as delivery vehicle for adenoviral vectors and imaging probes for gene therapy in glioblastoma. Methods: To use cord blood...
4.
Devpura S, Barton K, Brown S, Palyvoda O, Kalkanis S, Naik V, et al.
Med Phys
. 2014 May;
41(5):050901.
PMID: 24784365
Raman spectroscopy is an optical technique capable of identifying chemical constituents of a sample by their unique set of molecular vibrations. Research on the applicability of Raman spectroscopy in the...
5.
Altman M, Flynn M, Nishikawa R, Chetty I, Barton K, Movsas B, et al.
Med Hypotheses
. 2012 Nov;
80(1):94-8.
PMID: 23171625
Early detection through modalities such as mammography remains pivotal in the fight against breast cancer. The detectability of breast cancer through mammography is rooted in the differential X-ray attenuation properties...
6.
Barton K, Stricker H, Elshaikh M, Pegg J, Cheng J, Zhang Y, et al.
Mol Ther
. 2011 May;
19(7):1353-9.
PMID: 21587209
We have developed a replication-competent adenovirus (Ad5-yCD/mutTK(SR39)rep-hNIS) armed with two suicide genes and the human sodium iodide symporter (hNIS) gene. In this context, hNIS can be used as a reporter...
7.
Kumar S, Freytag S, Barton K, Burmeister J, Joiner M, Sedghi B, et al.
J Radiat Res
. 2010 Oct;
51(5):621-6.
PMID: 20921830
Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells. We present a novel strategy for sequestering boron using...
8.
Siddiqui F, Kolozsvary A, Barton K, Freytag S, Brown S, Kim J
Int J Hyperthermia
. 2009 May;
25(4):273-9.
PMID: 19452300
Purpose: Viral vectors used for cancer gene therapy are usually delivered by direct intratumoral administration. We studied the role of hyperthermia (HT) in vitro and in vivo in an attempt...
9.
Barton K, Stricker H, Brown S, Elshaikh M, Aref I, Lu M, et al.
Mol Ther
. 2008 Aug;
16(10):1761-9.
PMID: 18714306
To monitor noninvasively potentially therapeutic adenoviruses for cancer, we have developed a methodology based on the sodium iodide symporter (NIS). Men with clinically localized prostate cancer were administered an intraprostatic...
10.
Brown S, Freytag S, Barton K, Flynn M, Peck D, Dragovic A, et al.
Contrast Media Mol Imaging
. 2007 Dec;
2(5):240-7.
PMID: 18058866
The hypothesis that the human sodium-iodide symporter, NIS, can be used to detect NIS expression using standard radiological techniques was tested using adenoviral transduced NIS expression in human tumor xenografts...