Kenneth N Barton
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Explore the profile of Kenneth N Barton including associated specialties, affiliations and a list of published articles.
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18
Citations
394
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Recent Articles
11.
Barton K, Freytag S, Nurushev T, Yoo S, Lu M, Yin F, et al.
Hum Gene Ther
. 2007 Jun;
18(6):562-72.
PMID: 17594241
Optimization of adenoviral delivery to the target volume is required for adenovirus-mediated cancer gene therapy to reach its maximal potential. The purpose of these studies was to develop a model...
12.
Freytag S, Barton K, Brown S, Narra V, Zhang Y, Tyson D, et al.
Mol Ther
. 2007 Jun;
15(9):1600-6.
PMID: 17551507
In preparation for a Phase I trial, we evaluated the efficacy and toxicity of replication-competent adenovirus-mediated suicide gene therapy in combination with radiation in a preclinical model of pancreatic cancer....
13.
Siddiqui F, Barton K, Stricker H, Steyn P, LaRue S, Karvelis K, et al.
Hum Gene Ther
. 2007 Apr;
18(4):312-22.
PMID: 17408358
This study was done to aid in the design of a phase I gene therapy trial in patients with prostate cancer. We determined the dosimetric characteristics of our reporter gene...
14.
Freytag S, Movsas B, Aref I, Stricker H, Peabody J, Pegg J, et al.
Mol Ther
. 2007 Mar;
15(5):1016-23.
PMID: 17375076
Replication-competent adenovirus-mediated suicide gene therapy is an investigational cancer treatment in which an oncolytic adenovirus armed with chemo-radiosensitizing genes is used to destroy tumor cells. Previously, we evaluated the toxicity...
15.
Freytag S, Stricker H, Peabody J, Pegg J, Paielli D, Movsas B, et al.
Mol Ther
. 2007 Jan;
15(3):636-42.
PMID: 17228316
Replication-competent adenovirus-mediated suicide gene therapy is an investigational cancer treatment that combines the oncolytic actions of human adenoviruses with the cytotoxic effects of chemo-radiosensitizing genes. Previously, we reported the short-term...
16.
Barton K, Paielli D, Zhang Y, Koul S, Brown S, Lu M, et al.
Mol Ther
. 2005 Nov;
13(2):347-56.
PMID: 16290236
Replication-competent adenovirus-mediated suicide gene therapy has proven to be safe in humans when delivered intraprostatically. Although signs of efficacy are emerging, it is likely that further improvements will be needed...
17.
Barton K, Xia X, Yan H, Stricker H, Heisey G, Yin F, et al.
Mol Ther
. 2004 Apr;
9(4):625-31.
PMID: 15093193
This study describes a quantitative method to measure the magnitude and distribution of gene expression following local delivery of an adenoviral vector containing the human sodium iodide symporter (hNIS) reporter...
18.
Barton K, Tyson D, Stricker H, Lew Y, Heisey G, Koul S, et al.
Mol Ther
. 2003 Aug;
8(3):508-18.
PMID: 12946325
With the goal of optimizing adenovirus-mediated suicide gene therapy for prostate cancer, we have developed a method based on the human sodium iodide symporter (hNIS) that allows for noninvasive monitoring...