Kenneth G Macleod
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Explore the profile of Kenneth G Macleod including associated specialties, affiliations and a list of published articles.
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24
Citations
589
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0
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Recent Articles
11.
Johnstone M, Vasistha N, Barbu M, Dando O, Burr K, Christopher E, et al.
Mol Psychiatry
. 2018 Nov;
24(2):294-311.
PMID: 30401811
The molecular basis of how chromosome 16p13.11 microduplication leads to major psychiatric disorders is unknown. Here we have undertaken brain imaging of patients carrying microduplications in chromosome 16p13.11 and unaffected...
12.
Felton J, Lucas C, Dorward D, Duffin R, Kipari T, Vermeren S, et al.
J Allergy Clin Immunol
. 2018 Feb;
142(6):1884-1893.e6.
PMID: 29428392
Background: Eosinophils play a central role in propagation of allergic diseases, including asthma. Both recruitment and retention of eosinophils regulate pulmonary eosinophilia, but the question of whether alterations in apoptotic...
13.
Macleod K, Serrels B, Carragher N
Methods Mol Biol
. 2017 Aug;
1647:153-169.
PMID: 28809001
Reverse Phase Protein Arrays (RPPA) represent a sensitive antibody-based proteomic approach, which enables simultaneous quantification of the abundance of multiple proteins and posttranslational modifications across multiple samples. Here, we provide...
14.
Partolina M, Thoms H, Macleod K, Rodriguez-Blanco G, Clarke M, Venkatasubramani A, et al.
Cell Death Discov
. 2017 Mar;
3:16077.
PMID: 28326191
The balance between acetylation and deacetylation of histone proteins plays a critical role in the regulation of genomic functions. Aberrations in global levels of histone modifications are linked to carcinogenesis...
15.
Creedon H, Gomez-Cuadrado L, Tarnauskaite Z, Balla J, Canel M, Macleod K, et al.
Oncotarget
. 2016 Feb;
7(10):11539-52.
PMID: 26883193
Resistance to human epidermal growth factor receptor 2 (HER2)-targeted therapies in the treatment of HER2-positive breast cancer is a major clinical problem. To identify pathways linked to resistance, we generated...
16.
Sessa J, Larina E, Knoll K, Garb M, Cochran J, Huber B, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
112(51):15562-7.
PMID: 26630003
Ammonites are among the best-known fossils of the Phanerozoic, yet their habitat is poorly understood. Three common ammonite families (Baculitidae, Scaphitidae, and Sphenodiscidae) co-occur with well-preserved planktonic and benthic organisms...
17.
Weiss J, Dawson J, Macleod K, Rybski W, Fraser C, Torres-Sanchez C, et al.
Nat Commun
. 2014 Feb;
5:3277.
PMID: 24522696
A bioorthogonal organometallic reaction is a biocompatible transformation undergone by a synthetic material exclusively through the mediation of a non-biotic metal source; a selective process used to label biomolecules and...
18.
Secord R, Gingerich P, Lohmann K, Macleod K
Nature
. 2010 Oct;
467(7318):955-8.
PMID: 20962843
Marine and continental records show an abrupt negative shift in carbon isotope values at ∼55.8 Myr ago. This carbon isotope excursion (CIE) is consistent with the release of a massive...
19.
Schulte P, Alegret L, Arenillas I, Arz J, Barton P, Bown P, et al.
Science
. 2010 Mar;
327(5970):1214-8.
PMID: 20203042
The Cretaceous-Paleogene boundary approximately 65.5 million years ago marks one of the three largest mass extinctions in the past 500 million years. The extinction event coincided with a large asteroid...
20.
Kuske B, Naughton C, Moore K, Macleod K, Miller W, Clarke R, et al.
Endocr Relat Cancer
. 2006 Dec;
13(4):1121-33.
PMID: 17158758
Hormone-dependent estrogen receptor (ER)-positive breast cancer cells may adapt to low estrogen environments such as produced by aromatase inhibitors. In many instances, cells become insensitive to the effects of estrogen...