Kennan Marsh
Overview
Explore the profile of Kennan Marsh including associated specialties, affiliations and a list of published articles.
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60
Citations
1993
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Recent Articles
1.
Greenberg E, Voorbach M, Smith A, Reuter D, Zhuang Y, Wang J, et al.
Heliyon
. 2024 Sep;
10(16):e36483.
PMID: 39253182
Alzheimer's disease (AD) is the most common global dementia and is universally fatal. Most late-stage AD disease-modifying therapies are intravenous and target amyloid beta (Aβ), with only modest effects on...
2.
Savaryn J, Smith R, Rosebraugh M, Neenan M, Burton R, Marsh K, et al.
Pharmacol Res Perspect
. 2024 Apr;
12(2):e1190.
PMID: 38597598
Analysis was conducted to compare levodopa/carbidopa pharmacokinetics and drug-related material in plasma of healthy participants after receiving a continuous infusion of Levodopa/Carbidopa Intestinal Gel (LCIG) to a continuous subcutaneous infusion...
3.
Hulverson M, Choi R, Vidadala R, Whitman G, Vidadala V, Ojo K, et al.
ACS Infect Dis
. 2021 Feb;
7(5):1200-1207.
PMID: 33565854
Bumped kinase inhibitors (BKIs) that target calcium-dependent protein kinase 1 have been well established as potential drug candidates against cryptosporidiosis. Recently, BKI-1649, with a 7-pyrrolo[2,3-]pyrimidin-4-amine, or "pyrrolopyrimidine", central scaffold, has...
4.
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae
Hubner M, Koschel M, Struever D, Nikolov V, Frohberger S, Ehrens A, et al.
PLoS Negl Trop Dis
. 2019 Aug;
13(8):e0007636.
PMID: 31381563
Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4-6 weeks of doxycycline treatment can lead to permanent sterilization and adult filarial death. We investigated the anti-Wolbachia drug candidate ABBV-4083...
5.
Kosloski M, Bow D, Kikuchi R, Wang H, Kim E, Marsh K, et al.
J Pharmacol Exp Ther
. 2019 Jun;
370(2):278-287.
PMID: 31167814
Glecaprevir and pibrentasvir are oral direct-acting antiviral agents approved in combination for treatment of chronic hepatitis C viral infection. In vitro studies identified the combination as potentially clinically relevant inhibitors...
6.
Taylor M, von Geldern T, Ford L, Hubner M, Marsh K, Johnston K, et al.
Sci Transl Med
. 2019 Mar;
11(483).
PMID: 30867321
There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide...
7.
von Geldern T, Morton H, Clark R, Brown B, Johnston K, Ford L, et al.
PLoS Negl Trop Dis
. 2019 Mar;
13(2):e0007159.
PMID: 30818326
There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide)...
8.
Kling A, Jantos K, Mack H, Hornberger W, Drescher K, Nimmrich V, et al.
J Med Chem
. 2017 Aug;
60(16):7123-7138.
PMID: 28759231
Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading...
9.
McCarthy J, Lotharius J, Ruckle T, Chalon S, Phillips M, Elliott S, et al.
Lancet Infect Dis
. 2017 Apr;
17(6):626-635.
PMID: 28363636
Background: DSM265 is a novel antimalarial that inhibits plasmodial dihydroorotate dehydrogenase, an enzyme essential for pyrimidine biosynthesis. We investigated the safety, tolerability, and pharmacokinetics of DSM265, and tested its antimalarial...
10.
Phillips M, White K, Kokkonda S, Deng X, White J, El Mazouni F, et al.
ACS Infect Dis
. 2016 Sep;
2(12):945-957.
PMID: 27641613
The emergence of drug-resistant malaria parasites continues to hamper efforts to control this lethal disease. Dihydroorotate dehydrogenase has recently been validated as a new target for the treatment of malaria,...