Ken M Cadigan
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Explore the profile of Ken M Cadigan including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Zhang C, Blauwkamp T, Burby P, Cadigan K
PLoS Genet
. 2014 Aug;
10(8):e1004509.
PMID: 25144371
The Wnt/β-catenin signaling pathway plays many important roles in animal development, tissue homeostasis and human disease. Transcription factors of the TCF family mediate many Wnt transcriptional responses, promoting signal-dependent activation...
12.
Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila
Bhambhani C, Ravindranath A, Mentink R, Chang M, Betist M, Yang Y, et al.
PLoS Genet
. 2014 Feb;
10(2):e1004133.
PMID: 24516405
Regulation of gene expression by signaling pathways often occurs through a transcriptional switch, where the transcription factor responsible for signal-dependent gene activation represses the same targets in the absence of...
13.
Ravindranath A, Ravindranath A, Cadigan K
PLoS One
. 2014 Jan;
9(1):e86180.
PMID: 24465946
The evolutionarily conserved Wnt/ß-catenin (Wnt/ß-cat) pathway plays an important role in animal development in metazoans. Many Wnt targets are regulated by members of the TCF/LEF1 (TCF) family of transcription factors....
14.
Verkaar F, Cadigan K, van Amerongen R
Sci Signal
. 2012 Dec;
5(254):mr2.
PMID: 23233527
Wnt signal transduction is crucial for embryonic development and tissue homeostasis in multicellular animals. Hyperactivation of the Wnt pathway drives tumor formation, yet activation of the Wnt pathway in stem...
15.
Cadigan K, Waterman M
Cold Spring Harb Perspect Biol
. 2012 Oct;
4(11).
PMID: 23024173
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are multifunctional proteins that use their sequence-specific DNA-binding and context-dependent interactions...
16.
Cadigan K
Curr Top Dev Biol
. 2012 Feb;
98:1-34.
PMID: 22305157
Wnts are conserved, secreted signaling proteins that can influence cell behavior by stabilizing β-catenin. Accumulated β-catenin enters the nucleus, where it physically associates with T-cell factor (TCF) family members to...
17.
Kennell J, Cadigan K, Shakhmantsir I, Waldron E
Dev Dyn
. 2011 Dec;
241(1):161-8.
PMID: 22174085
Background: MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally silence gene expression by binding to target mRNAs. Previous studies have identified the miRNA miR-8 as a pleiotropic regulator of Drosophila...
18.
Bhambhani C, Chang J, Akey D, Cadigan K
EMBO J
. 2011 Apr;
30(10):2031-43.
PMID: 21468031
C-terminal-binding protein (CtBP) is a well-characterized transcriptional co-repressor that requires homo-dimerization for its activity. CtBP can both repress and activate Wingless nuclear targets in Drosophila. Here, we examine the role...
19.
20.
Cadigan K, Peifer M
Cold Spring Harb Perspect Biol
. 2010 Jan;
1(2):a002881.
PMID: 20066091
One of the early surprises in the study of cell adhesion was the discovery that beta-catenin plays dual roles, serving as an essential component of cadherin-based cell-cell adherens junctions and...