Ken M Cadigan
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Explore the profile of Ken M Cadigan including associated specialties, affiliations and a list of published articles.
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40
Citations
1751
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Recent Articles
1.
Stewart R, Ding Z, Jeon U, Goodman L, Tran J, Zientko J, et al.
PLoS Biol
. 2024 Sep;
22(9):e3002368.
PMID: 39316611
The Wnt/β-catenin signaling pathway plays numerous essential roles in animal development and tissue/stem cell maintenance. The activation of genes regulated by Wnt/β-catenin signaling requires the nuclear accumulation of β-catenin, a...
2.
Ramakrishnan A, Burby P, Adiga K, Cadigan K
J Biol Chem
. 2022 Nov;
299(1):102735.
PMID: 36423688
Activation of the Wnt/β-catenin pathway regulates gene expression by promoting the formation of a β-catenin-T-cell factor (TCF) complex on target enhancers. In addition to TCFs, other transcription factors interact with...
3.
Ramakrishnan A, Chen L, Burby P, Cadigan K
Nucleic Acids Res
. 2021 Aug;
49(15):8625-8641.
PMID: 34358319
Transcriptional regulation by Wnt signalling is primarily thought to be accomplished by a complex of β-catenin and TCF family transcription factors (TFs). Although numerous studies have suggested that additional TFs...
4.
Sinha A, Fan V, Ramakrishnan A, Engelhardt N, Kennell J, Cadigan K
Sci Adv
. 2021 Feb;
7(8).
PMID: 33597243
Wnt/β-catenin signaling requires inhibition of a multiprotein destruction complex that targets β-catenin for proteasomal degradation. SOX9 is a potent antagonist of the Wnt pathway and has been proposed to act...
5.
Stewart R, Ramakrishnan A, Cadigan K
PLoS Genet
. 2019 Jun;
15(6):e1008154.
PMID: 31194739
No abstract available.
6.
Ramakrishnan A, Sinha A, Fan V, Cadigan K
Bioessays
. 2017 Dec;
40(2).
PMID: 29250807
Many targets of the Wnt/β-catenin signaling pathway are regulated by TCF transcription factors, which play important roles in animal development, stem cell biology, and oncogenesis. TCFs can regulate Wnt targets...
7.
Ramakrishnan A, Cadigan K
F1000Res
. 2017 Jun;
6:746.
PMID: 28649368
Wnt/β-catenin signaling is highly conserved throughout metazoans, is required for numerous essential events in development, and serves as a stem cell niche signal in many contexts. Misregulation of the pathway...
8.
Zhang C, Cadigan K
Development
. 2017 May;
144(13):2415-2427.
PMID: 28526755
The lymph gland (LG) is a major source of hematopoiesis during development. In this tissue, prohemocytes differentiate into multiple lineages, including macrophage-like plasmatocytes, which comprise the vast majority of mature...
9.
Ravindranath A, Cadigan K
Cancers (Basel)
. 2016 Aug;
8(8).
PMID: 27527215
T-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of...
10.
Archbold H, Broussard C, Chang M, Cadigan K
PLoS Genet
. 2014 Sep;
10(9):e1004591.
PMID: 25188465
The T-cell factor (TCF) family of transcription factors are major mediators of Wnt/β-catenin signaling in metazoans. All TCFs contain a High Mobility Group (HMG) domain that possesses specific DNA binding...