Ken C Dong
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Explore the profile of Ken C Dong including associated specialties, affiliations and a list of published articles.
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22
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1413
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Recent Articles
1.
Arkinson C, Gee C, Zhang Z, Dong K, Martin A
bioRxiv
. 2024 Nov;
PMID: 39574680
The 26S proteasome targets many cellular proteins for degradation during general homeostasis, protein quality control, and the regulation of vital processes. A broad range of proteasome-interacting cofactors thereby modulates these...
2.
Htet Z, Dong K, Martin A
bioRxiv
. 2024 Nov;
PMID: 39484543
The 26S proteasome is the major compartmental protease in eukaryotic cells, responsible for the ATP-dependent turnover of obsolete, damaged, or misfolded proteins that are delivered for degradation through attached ubiquitin...
3.
Arkinson C, Dong K, Gee C, Martin A
Nat Rev Mol Cell Biol
. 2024 Oct;
26(2):104-122.
PMID: 39362999
The 26S proteasome is involved in degrading and regulating the majority of proteins in eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this Review, we discuss...
4.
Arkinson C, Dong K, Gee C, Costello S, Marqusee S, Martin A
bioRxiv
. 2024 Jun;
PMID: 38915702
The ubiquitin-like modifier FAT10 targets hundreds of proteins in the mammalian immune system to the 26S proteasome for degradation. This degradation pathway requires the cofactor Nub1, yet the underlying mechanisms...
5.
Williams C, Dong K, Arkinson C, Martin A
STAR Protoc
. 2023 Oct;
4(4):102659.
PMID: 37889757
A critical step in the removal of polyubiquitinated proteins from macromolecular complexes and membranes for subsequent proteasomal degradation is the unfolding of an ubiquitin moiety by the cofactor Ufd1/Npl4 (UN)...
6.
Williams C, Dong K, Arkinson C, Martin A
Mol Cell
. 2023 Feb;
83(5):759-769.e7.
PMID: 36736315
The AAA+ ATPase Cdc48 utilizes the cofactor Ufd1/Npl4 to bind and thread polyubiquitinated substrates for their extraction from complexes or membranes and often for subsequent proteasomal degradation. Previous studies indicated...
7.
Jonsson E, Htet Z, Bard J, Dong K, Martin A
Sci Adv
. 2022 Dec;
8(51):eadd9520.
PMID: 36563145
The 26 proteasome recognizes thousands of appropriate protein substrates in eukaryotic cells through attached ubiquitin chains and uses its adenosine triphosphatase (ATPase) motor for mechanical unfolding and translocation into a...
8.
Xie G, Dong K, Worden E, Martin A
Methods Mol Biol
. 2022 Nov;
2591:79-100.
PMID: 36350544
Rpn11 is an essential metalloprotease responsible for the en bloc removal of ubiquitin chains from protein substrates that are targeted for degradation by the 26S proteasome. A unique feature of...
9.
Greene E, Dong K, Martin A
Curr Opin Struct Biol
. 2019 Nov;
61:33-41.
PMID: 31783300
The 26S proteasome is the essential compartmental protease in eukaryotic cells required for the ubiquitin-dependent clearance of damaged polypeptides and obsolete regulatory proteins. Recently, a combination of high-resolution structural, biochemical,...
10.
Bard J, Bashore C, Dong K, Martin A
Cell
. 2019 Apr;
177(2):286-298.e15.
PMID: 30929903
The 26S proteasome is the principal macromolecular machine responsible for protein degradation in eukaryotes. However, little is known about the detailed kinetics and coordination of the underlying substrate-processing steps of...