Ken-Ichiro Hayashida
Overview
Explore the profile of Ken-Ichiro Hayashida including associated specialties, affiliations and a list of published articles.
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42
Citations
675
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Recent Articles
1.
Hayashida K, Eisenach J, Kawatani M, Martin T
J Physiol Sci
. 2019 Jul;
69(5):769-777.
PMID: 31267368
Operant methods that allow animals to avoid painful stimuli are interpreted to assess the aversive quality of pain; however, such measurements require investigator-initiated stimuli to animals. Here we developed a...
2.
Hayashida K, Obata H
Int J Mol Sci
. 2019 Feb;
20(4).
PMID: 30769838
Gabapentinoids (gabapentin and pregabalin) and antidepressants (tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors) are often used to treat chronic pain. The descending noradrenergic inhibitory system from the locus coeruleus (LC)...
3.
Hayashida K, Eisenach J
Adv Exp Med Biol
. 2018 Oct;
1099:93-100.
PMID: 30306517
Gabapentinoids are effective in a wide range of animal pain models and in patients with neuropathic pain and has become one of first-line treatments for neuropathic pain. Because spinal plasticity...
4.
Hayashida K, Kimuram M, Eisenach J
Neurosci Lett
. 2018 Apr;
676:41-45.
PMID: 29627342
Locus coeruleus (LC)-spinal noradrenergic projections are important to endogenous analgesic mechanisms and can be activated by local glutamate signaling in the LC. The current study examined the local glutamatergic, GABAergic,...
5.
Shiina K, Hayashida K, Ishikawa K, Kawatani M
Biomed Res
. 2016 Oct;
37(5):299-304.
PMID: 27784873
Overactive bladder is one of the major health problem especially in elderly people. Adenosine triphosphate (ATP) is released from urinary bladder cells and acts as a smooth muscle contraction and...
6.
Kimura M, Eisenach J, Hayashida K
Pain
. 2016 Jun;
157(9):2024-2032.
PMID: 27315512
Despite being one of the first-choice analgesics for chronic neuropathic pain, gabapentin sometimes fails to provide analgesia, but the mechanisms for this lack of efficacy is unclear. Rats with nerve...
7.
Arora V, Morado-Urbina C, Aschenbrenner C, Hayashida K, Wang F, Martin T, et al.
J Pain
. 2015 Nov;
17(2):190-202.
PMID: 26545342
Unlabelled: Results of clinical studies suggest that descending inhibitory controls from the brainstem are important for speeding recovery from pain after surgery. We examined the effects of destroying spinally projecting...
8.
Kimura M, Suto T, Eisenach J, Hayashida K
Neurosci Lett
. 2015 Oct;
608:18-22.
PMID: 26450532
Descending noradrenergic inhibition to the spinal cord from the locus coeruleus (LC) is an important endogenous pain-relief mechanism which can be activated by local glutamate signaling. Here we tested whether...
9.
Kimura M, Suto T, Morado-Urbina C, Peters C, Eisenach J, Hayashida K
Anesthesiology
. 2015 Aug;
123(4):899-908.
PMID: 26244888
Background: Patients with neuropathic pain show reduced endogenous analgesia induced by a conditioned noxious stimulus. Here, the authors tested whether peripheral nerve injury impairs descending noradrenergic inhibition from the locus...
10.
Peters C, Hayashida K, Suto T, Houle T, Aschenbrenner C, Martin T, et al.
Anesthesiology
. 2015 Jan;
122(4):895-907.
PMID: 25581910
Background: Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and...