Hideaki Obata
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Explore the profile of Hideaki Obata including associated specialties, affiliations and a list of published articles.
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64
Citations
836
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Recent Articles
1.
Kasahara S, Takahashi M, Suto T, Morita T, Obata H, Niwa S
Front Pharmacol
. 2025 Mar;
16:1500313.
PMID: 40078279
Chronic pain affects a significant portion of adults and is linked to psychosocial issues, cognitive dysfunction, and psychiatric disorders, complicating treatment. Attention deficit hyperactivity disorder (ADHD) is increasingly recognized as...
2.
Suto T, Kato D, Koibuchi I, Arai Y, Ohta J, Hiroki T, et al.
Sci Rep
. 2023 Apr;
13(1):5526.
PMID: 37016045
Chronic pain and attention-deficit hyperactivity disorder (ADHD) frequently coexist. However, the common pathology is still unclear. Attenuated noradrenergic endogenous analgesia can produce acute pain chronification, and dysfunction of noradrenergic systems...
3.
Hiroki T, Fujita N, Suto T, Suzuki H, Tsukamoto N, Ohta J, et al.
Medicine (Baltimore)
. 2022 Dec;
101(50):e32306.
PMID: 36550823
Background: This prospective, randomized, double-blinded, active controlled trial assessed whether a single preoperative administration of 40 mg of duloxetine could decrease postoperative pain and numbness after posterior lumbar interbody fusion...
4.
Kimura H, Suda M, Kobayashi T, Suzuki S, Fukui S, Obata H
Sci Rep
. 2022 Nov;
12(1):19782.
PMID: 36396688
We conducted a prospective single-arm interventional study of the treatment efficacy of ultrasound-guided fascia hydrorelease (US-FHR) on the coracohumeral ligament (CHL) of patients with global limitation of shoulder range of...
5.
Kato D, Suto T, Obata H, Saito S
IBRO Neurosci Rep
. 2022 Mar;
12:188-196.
PMID: 35243478
Antidepressants, such as duloxetine, are widely used to treat chronic pain, including neuropathic pain; however, their efficacy is unsatisfactory. In our previous studies, we showed that in a spinal nerve...
6.
Hiroki T, Suto T, Ohta J, Saito S, Obata H
J Pain
. 2021 Oct;
23(4):547-557.
PMID: 34678470
Systemic administration of morphine increases serotonin (5-HT) in the spinal dorsal horn (SDH), which attenuates the analgesic effects of morphine on neuropathic pain through spinal 5-HT3 receptors. We hypothesized that...
7.
Ohta J, Suto T, Kato D, Hiroki T, Obata H, Saito S
Brain Res
. 2019 Dec;
1727:146568.
PMID: 31785233
Background: Preoperative pain and impaired endogenous analgesia are risk factors of chronic postsurgical persistent pain (CPSP). A Chronic neuropathic pain model induced by spinal nerve ligation (SNL6W) shows impaired endogenous...
8.
Hayashida K, Obata H
Int J Mol Sci
. 2019 Feb;
20(4).
PMID: 30769838
Gabapentinoids (gabapentin and pregabalin) and antidepressants (tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors) are often used to treat chronic pain. The descending noradrenergic inhibitory system from the locus coeruleus (LC)...
9.
Suto T, Kato D, Obata H, Saito S
J Pain
. 2018 Dec;
20(5):600-609.
PMID: 30529695
A rat model of neuropathic pain at 6 weeks after spinal nerve ligation (SNL6w) exhibits both mechanical hypersensitivity and impaired noxious stimuli-induced analgesia (NSIA). Repeated treatment with antidepressants can produce...
10.
Kato D, Suto T, Obata H, Saito S
Anesth Analg
. 2018 Jun;
129(2):578-586.
PMID: 29933273
Background: Although endogenous analgesia plays an important role in controlling pain states, chronic pain patients exhibit decreased endogenous analgesia compared to healthy individuals. In rats, noxious stimulus-induced analgesia (NSIA), which...