Ken-ichi Yamada
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Explore the profile of Ken-ichi Yamada including associated specialties, affiliations and a list of published articles.
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Articles
187
Citations
1776
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Recent Articles
1.
Sun C, Nishikawa H, Inokuma T, Yamada K
Molecules
. 2025 Jan;
30(2).
PMID: 39860238
Diastereodivergent synthesis of octahydrophenanthridinone and octahydrophenanthridine skeletons, structural motifs often found in biologically active natural products, is described. We previously reported a total synthesis of a pancratistatin analog using novel...
2.
Lerksaipheng P, Paiboonsukwong K, Sanvarinda P, Luechapudiporn R, Yamada K, Morales N
Free Radic Biol Med
. 2024 Sep;
224:618-629.
PMID: 39303953
Iron overload results in lipid peroxidation (LPO) and the oxidative modification of circulating lipoproteins, which contributes to cardiovascular complications in patients with β-thalassemia. Investigating LPO may provide opportunities for the...
3.
Sun C, Inokuma T, Tsuji D, Yamaoka Y, Akagi R, Yamada K
Chem Commun (Camb)
. 2024 Jun;
60(53):6757-6760.
PMID: 38864269
The total synthesis of 1,4a-di--pancratistatin, a novel stereoisomer of the anti-tumor alkaloid pancratistatin, was achieved in 14 steps starting from D-mannitol. The construction of the pancratistatin skeleton involved conjugate addition...
4.
Mori R, Abe M, Saimoto Y, Shinto S, Jodai S, Tomomatsu M, et al.
Redox Biol
. 2024 May;
73:103186.
PMID: 38744193
Recent studies have highlighted the indispensable role of oxidized lipids in inflammatory responses, cell death, and disease pathogenesis. Consequently, inhibitors targeting oxidized lipids, particularly lipid-derived radicals critical in lipid peroxidation,...
5.
Yamato M, Kato N, Yamada K, Inoguchi T
Diabetes
. 2024 Apr;
73(7):1153-1166.
PMID: 38608284
Article Highlights:
6.
Tsuruta K, Matsuoka M, Harada S, Enomoto A, Kumagai T, Yasuda S, et al.
J Clin Biochem Nutr
. 2024 Mar;
74(2):97-107.
PMID: 38510679
Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme that reduces phospholipid hydroperoxide. Studies have reported that the loss of GPx4 activity through anticancer drugs leads to ferroptosis, an iron-dependent lipid...
7.
Tomomatsu M, Imamura N, Izumi H, Watanabe M, Ikeda M, Ide T, et al.
Biol Pharm Bull
. 2024 Mar;
47(3):641-651.
PMID: 38508744
Recently, mitochondrial dysfunction has gained attention as a causative factor in the pathogenesis and progression of age-related macular degeneration (AMD). Mitochondrial damage plays a key role in metabolism and disrupts...
8.
Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, et al.
Nat Commun
. 2024 Mar;
15(1):2195.
PMID: 38472233
Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), the terminal enzyme...
9.
Bo T, Nohara H, Yamada K, Miyata S, Fujii J
Antioxidants (Basel)
. 2024 Feb;
13(2).
PMID: 38397750
Bone marrow cells are the most sensitive to exposure to X-rays in the body and are selectively damaged even by doses that are generally considered permissive in other organs. Ascorbic...
10.
Abe M, Sou M, Matsuoka Y, Morimoto K, Yamada K
Biol Pharm Bull
. 2024 Jan;
47(1):104-111.
PMID: 38171771
White matter lesions induced by chronic cerebral hypoperfusion can cause vascular dementia; however, no appropriate treatments are currently available for these diseases. In this study, we investigated lipid peroxidation, which...