Ken-ichi Yamada
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Explore the profile of Ken-ichi Yamada including associated specialties, affiliations and a list of published articles.
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187
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1776
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Recent Articles
11.
Ishimaru K, Ikeda M, Miyamoto H, Furusawa S, Abe K, Watanabe M, et al.
J Am Heart Assoc
. 2023 Dec;
13(1):e031219.
PMID: 38158218
Background: Ferroptosis, an iron-dependent form of regulated cell death, is a major cell death mode in myocardial ischemia reperfusion (I/R) injury, along with mitochondrial permeability transition-driven necrosis, which is inhibited...
12.
Sugano M, Inokuma T, Yamaoka Y, Yamada K
Org Biomol Chem
. 2023 Dec;
22(9):1765-1769.
PMID: 38099597
We developed a novel thiourea Lewis-base catalyst with phenol moieties for the enantioselective 5--bromolactonization of stilbenecarboxylic acids to afford chiral 3-substituted phthalides. The phenol moieties are crucial for the enantio-...
13.
Yamada K, Inokuma T
RSC Adv
. 2023 Dec;
13(51):35904-35910.
PMID: 38090087
-values of 20 substituents were estimated by quantum chemistry calculations of different theoretical levels. Comparison with the reported experimental values provided a good benchmark to evaluate the theoretical levels for...
14.
Ichihara G, Katsumata Y, Sugiura Y, Matsuoka Y, Maeda R, Endo J, et al.
Circ Res
. 2023 Oct;
133(10):861-876.
PMID: 37818671
Background: The membrane components of cardiomyocytes are rich in polyunsaturated fatty acids, which are easily oxidized. Thus, an efficient glutathione-based lipid redox system is essential for maintaining cellular functions. However,...
15.
Fujii J, Yamada K
Free Radic Res
. 2023 Aug;
57(5):353-372.
PMID: 37551716
The presence of hydrogen peroxide along with ferrous iron produces hydroxyl radicals that preferably oxidize polyunsaturated fatty acids (PUFA) to alkyl radicals (L•). The reaction of L• with an oxygen...
16.
Inokuma T, Yamada K
Chem Rec
. 2023 May;
23(7):e202300103.
PMID: 37255345
Our recent efforts to develop novel N-Heterocyclic carbene (NHC)-catalyzed asymmetric reactions are described. During our investigation for development of the acylation reactions via acylazoliums generated by the reactions of NHCs...
17.
Remote Electronic Effect of Chiral N-Heterocyclic Carbene Catalyst on an Asymmetric Benzoin Reaction
Inokuma T, Hashimoto K, Fujiwara T, Sun C, Kuwano S, Yamada K
Chemistry
. 2023 Apr;
29(38):e202300858.
PMID: 37067457
A remote electronic effect of chiral aminoindanol-derived N-heterocyclic carbene catalyst on an asymmetric benzoin reaction was investigated. The catalyst bearing remote electron-withdrawing substituents increased enantioselectivity of the reaction at the...
18.
Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, et al.
JCI Insight
. 2023 Mar;
8(6).
PMID: 36946465
No abstract available.
19.
Inokuma T, Iritani K, Takahara Y, Sun C, Yamaoka Y, Kuwano S, et al.
Chem Commun (Camb)
. 2023 Mar;
59(36):5375-5378.
PMID: 36939087
The remote electronic effects of chiral N-heterocyclic carbene catalysts on the asymmetric intramolecular Stetter reaction are investigated. The reaction rate and enantioselectivity were markedly influenced by a substituent at a...
20.
Ueno M, Shibata S, Nakanishi I, Aoki I, Yamada K, Matsumoto K
J Clin Biochem Nutr
. 2023 Mar;
72(2):107-116.
PMID: 36936873
The impact of radiation-induced hydrogen peroxide (HO) on the biological effects of X-rays and carbon-ion beams was investigated using a selenium-deficient (SeD) mouse model. Selenium is the active center of...