Ken-Ichi Aisaki
Overview
Explore the profile of Ken-Ichi Aisaki including associated specialties, affiliations and a list of published articles.
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24
Citations
326
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Recent Articles
1.
Hase T, Ghosh S, Aisaki K, Kitajima S, Kanno J, Kitano H, et al.
J Toxicol Sci
. 2024 Mar;
49(3):105-115.
PMID: 38432953
With the advancement of large-scale omics technologies, particularly transcriptomics data sets on drug and treatment response repositories available in public domain, toxicogenomics has emerged as a key field in safety...
2.
Aisaki K, Ono R, Kanno J, Kitajima S
Nihon Yakurigaku Zasshi
. 2022 May;
157(3):200-206.
PMID: 35491119
We are constructing the "Percellome Database" containing many transcriptomes of mice exposed to a series of chemicals to elucidate the molecular mechanism of toxicity and to develop toxicity prediction technology....
3.
Nock R, Polouliakh N, Nielsen F, Oka K, Connell C, Heimhofer C, et al.
PLoS One
. 2020 Jul;
15(7):e0233755.
PMID: 32628677
Systems biology aims at holistically understanding the complexity of biological systems. In particular, nowadays with the broad availability of gene expression measurements, systems biology challenges the deciphering of the genetic...
4.
Exosome-mediated horizontal gene transfer occurs in double-strand break repair during genome editing
Ono R, Yasuhiko Y, Aisaki K, Kitajima S, Kanno J, Hirabayashi Y
Commun Biol
. 2019 Feb;
2:57.
PMID: 30775458
The CRISPR-Cas9 system has been successfully applied in many organisms as a powerful genome-editing tool. Undoubtedly, it will soon be applied to human genome editing, including gene therapy. We have...
5.
Furukawa Y, Tanemura K, Igarashi K, Ideta-Otsuka M, Aisaki K, Kitajima S, et al.
Front Neurosci
. 2016 Aug;
10:339.
PMID: 27489535
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian central nervous system, is also known to be important for brain development. Therefore, disturbances of GABA receptor (GABA-R) mediated signaling...
6.
Tanaka M, Aisaki K, Kitajima S, Igarashi K, Kanno J, Nakamura T
Genom Data
. 2015 Oct;
2:296-8.
PMID: 26484113
Ewing's sarcoma is a rare bone tumor that affects children and adolescents. We have recently succeeded to induce Ewing's sarcoma-like small round cell tumor in mice by expression of EWS-ETS...
7.
8.
Tanaka M, Yamazaki Y, Kanno Y, Igarashi K, Aisaki K, Kanno J, et al.
J Clin Invest
. 2014 Jun;
124(7):3061-74.
PMID: 24911143
Ewing's sarcoma is a highly malignant bone tumor found in children and adolescents, and the origin of this malignancy is not well understood. Here, we introduced a Ewing's sarcoma-associated genetic...
9.
Janesick A, Nguyen T, Aisaki K, Igarashi K, Kitajima S, Chandraratna R, et al.
Development
. 2014 May;
141(11):2260-70.
PMID: 24821986
Retinoic acid receptor gamma 2 (RARγ2) is the major RAR isoform expressed throughout the caudal axial progenitor domain in vertebrates. During a microarray screen to identify RAR targets, we identified...
10.
Kanno J, Aisaki K, Igarashi K, Kitajima S, Matsuda N, Morita K, et al.
J Toxicol Sci
. 2013 Jul;
38(4):643-54.
PMID: 23892564
Pentachlorophenol (PCP) was monitored for transcriptome responses in adult mouse liver at 2, 4, 8 and 24 hr after a single oral administration at four dose levels, 0, 10, 30...