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Kelly T Hughes

Explore the profile of Kelly T Hughes including associated specialties, affiliations and a list of published articles. Areas
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Articles 91
Citations 3175
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Recent Articles
1.
Schrock M, Parsawar K, Hughes K, Chevance F
PLoS Genet . 2025 Feb; 21(2):e1011569. PMID: 39903774
The efficiency with which aminoacyl-tRNA and GTP-bound translation elongation factor EF-Tu recognizes the A-site codon of the ribosome is dependent on codons and tRNA species present in the polypeptide (P)...
2.
Johnson S, Deme J, Furlong E, Caesar J, Chevance F, Hughes K, et al.
Res Sq . 2024 Aug; PMID: 39108497
The bacterial flagellum is a macromolecular protein complex that harvests energy from ion-flow across the inner membrane to power bacterial swimming in viscous fluids via rotation of the flagellar filament....
3.
Halte M, Andrianova E, Goosmann C, Chevance F, Hughes K, Zhulin I, et al.
Nat Commun . 2024 Jul; 15(1):5921. PMID: 39004688
The bacterial flagellum, which facilitates motility, is composed of ~20 structural proteins organized into a long extracellular filament connected to a cytoplasmic rotor-stator complex via a periplasmic rod. Flagellum assembly...
4.
Halte M, Andrianova E, Goosmann C, Chevance F, Hughes K, Zhulin I, et al.
bioRxiv . 2024 Apr; PMID: 38558991
The bacterial flagellum is an organelle utilized by many Gram-negative bacteria to facilitate motility. The flagellum is composed of a several µm long, extracellular filament that is connected to a...
5.
Johnson S, Deme J, Furlong E, Caesar J, Chevance F, Hughes K, et al.
Nat Microbiol . 2024 Mar; 9(5):1282-1292. PMID: 38459206
The bacterial flagellum is a macromolecular protein complex that harvests energy from uni-directional ion flow across the inner membrane to power bacterial swimming via rotation of the flagellar filament. Rotation...
6.
Wozniak C, Hughes K, Liou T
J Bacteriol . 2023 Sep; 205(10):e0020723. PMID: 37730541
serovar Typhimurium strain LT2 is protected by two DNA restriction-modification systems (HsdRMS and Mod-Res) and a Type I bacteriophage exclusion (BREX) system (BrxA-L). The LB5000 strain was constructed to inactivate...
7.
Chevance F, Hughes K
Bio Protoc . 2023 Jul; 13(12):e4696. PMID: 37397791
Export of type 3 secretion (T3S) substrates is traditionally evaluated using trichloroacetic acid (TCA) precipitation of cultured cell supernatants followed by western blot analysis of the secreted substrates. In our...
8.
Qu D, Jiang M, Duffin C, Hughes K, Chevance F
PLoS Genet . 2022 Jul; 18(7):e1010313. PMID: 35819991
The Salmonella flagellar secretion apparatus is a member of the type III secretion (T3S) family of export systems in bacteria. After completion of the flagellar motor structure, the hook-basal body...
9.
Hendriksen J, Lee H, Bradshaw A, Namba K, Chevance F, Minamino T, et al.
mBio . 2021 Sep; 12(5):e0239221. PMID: 34579566
The FliE component of the bacterial flagellum is the first protein secreted through the flagellar type III secretion system (fT3SS) that is capable of self-assembly into the growing bacterial organelle....
10.
Johnson S, Furlong E, Deme J, Nord A, Caesar J, Chevance F, et al.
Nat Microbiol . 2021 May; 6(6):712-721. PMID: 33931760
The bacterial flagellum is a macromolecular protein complex that enables motility in many species. Bacterial flagella self-assemble a strong, multicomponent drive shaft that couples rotation in the inner membrane to...