Kelly Suino-Powell
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Explore the profile of Kelly Suino-Powell including associated specialties, affiliations and a list of published articles.
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26
Citations
1758
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Recent Articles
1.
Schultz C, Aleiwi B, Zhou X, Suino-Powell K, Melcher K, Almeida N, et al.
J Med Chem
. 2025 Mar;
68(5):5760-5773.
PMID: 40035393
We here describe the design, synthesis, and biological activity of novel ornithine decarboxylase (ODC) inhibitors that show significantly higher potency than α-difluoromethylornithine (DFMO), a U.S. Food and Drug Administration (FDA)...
2.
Kariapper L, Marathe I, Niesman A, Suino-Powell K, Chook Y, Wysocki V, et al.
bioRxiv
. 2025 Jan;
PMID: 39764026
Histone H3K9 methylation (H3K9me) by Setdb1 silences retrotransposons (rTE) by sequestering them in constitutive heterochromatin. Atf7IP is a constitutive binding partner of Setdb1 and is responsible for Setdb1 nuclear localization,...
3.
Zhou X, Zhang Y, Yao J, Zheng J, Zhou Y, He Q, et al.
Plant Commun
. 2023 Jun;
4(6):100639.
PMID: 37322867
Jasmonates (JAs) are plant hormones with crucial roles in development and stress resilience. They activate MYC transcription factors by mediating the proteolysis of MYC inhibitors called JAZ proteins. In the...
4.
Zhou X, Suino-Powell K, Schultz C, Aleiwi B, Brunzelle J, Lamp J, et al.
Biochem J
. 2021 Nov;
478(23):4137-4149.
PMID: 34796899
Ornithine decarboxylase (ODC) is the rate-limiting enzyme for the synthesis of polyamines (PAs). PAs are oncometabolites that are required for proliferation, and pharmaceutical ODC inhibition is pursued for the treatment...
5.
Yan Y, Mukherjee S, Harikumar K, Strutzenberg T, Zhou X, Suino-Powell K, et al.
Science
. 2021 Aug;
373(6553):413-419.
PMID: 34437114
Adenosine monophosphate (AMP)-activated protein kinase (AMPK) regulates metabolism in response to the cellular energy states. Under energy stress, AMP stabilizes the active AMPK conformation, in which the kinase activation loop...
6.
Jiang H, Zhou X, Shi J, Zhou Z, Zhao G, Zhang X, et al.
Chem Sci
. 2020 Mar;
11(8):2260-2268.
PMID: 32190280
Peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of glucose homeostasis and lipid metabolism, and an important target for the development of modern anti-diabetic drugs. However, current PPARγ-targeting anti-diabetic...
7.
Yang S, Wu Y, Xu T, de Waal P, He Y, Pu M, et al.
Nature
. 2018 Aug;
560(7720):666-670.
PMID: 30135577
Frizzled receptors (FZDs) are class-F G-protein-coupled receptors (GPCRs) that function in Wnt signalling and are essential for developing and adult organisms. As central mediators in this complex signalling pathway, FZDs...
8.
Yi W, Shi J, Zhao G, Zhou X, Suino-Powell K, Melcher K, et al.
Sci Rep
. 2017 Jan;
7:41487.
PMID: 28128331
Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but their therapeutic benefits are compromised by severe side effects....
9.
Fu T, Kim Y, Byun S, Kim D, Seok S, Suino-Powell K, et al.
Mol Endocrinol
. 2015 Oct;
30(1):92-103.
PMID: 26505219
The bile acid (BA)-sensing nuclear receptor, farnesoid X receptor (FXR), regulates postprandial metabolic responses, including inhibition of BA synthesis, by inducing the intestinal hormone, fibroblast growth factor (FGF)15 (FGF19 in...
10.
Fu T, Seok S, Choi S, Huang Z, Suino-Powell K, Xu H, et al.
Mol Cell Biol
. 2014 Sep;
34(22):4130-42.
PMID: 25182532
Brown fat generates heat through uncoupled respiration, protecting against hypothermia and obesity. Adult humans have brown fat, but the amounts and activities are substantially decreased in obesity, by unknown mechanisms....