Kellee R Siegfried
Overview
Explore the profile of Kellee R Siegfried including associated specialties, affiliations and a list of published articles.
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23
Citations
674
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Recent Articles
1.
Kawasaki T, Nishimura T, Tani N, Ramos C, Karaulanov E, Shinya M, et al.
bioRxiv
. 2024 Nov;
PMID: 39605693
Ribosome biogenesis is vital for sustaining stem cell properties, yet its regulatory mechanisms are obscure. Herein, we show unique properties of zebrafish mutants in which spermatogonial stem cells (SSCs) do...
2.
Wang Z, Townley S, Zhang S, Liu M, Li M, Labaf M, et al.
Nat Commun
. 2024 Jun;
15(1):4914.
PMID: 38851846
FOXA family proteins act as pioneer factors by remodeling compact chromatin structures. FOXA1 is crucial for the chromatin binding of the androgen receptor (AR) in both normal prostate epithelial cells...
3.
Han D, Labaf M, Zhao Y, Owiredu J, Zhang S, Patel K, et al.
J Clin Invest
. 2024 Apr;
134(11).
PMID: 38687617
One critical mechanism through which prostate cancer (PCa) adapts to treatments targeting androgen receptor (AR) signaling is the emergence of ligand-binding domain-truncated and constitutively active AR splice variants, particularly AR-V7....
4.
Besschetnova A, Han W, Liu M, Gao Y, Li M, Wang Z, et al.
Cancer Res Commun
. 2023 Sep;
3(8):1716-1730.
PMID: 37663929
Significance: In this study, we demonstrate that EHMT1 and EHMT2 proteins drive prostate cancer development by transcriptionally activating multiple oncogenic pathways. Mechanistically, the chromatin binding of EHMT1 is significantly expanded...
5.
Li C, Boldt H, Parent E, Ficklin J, James A, Anlage T, et al.
J Exp Zool B Mol Dev Evol
. 2023 Aug;
342(3):164-177.
PMID: 37553824
Kryptolebias marmoratus (Kmar), a teleost fish of the order Cyprinodontiformes, has a suite of unique phenotypes and behaviors not observed in other fishes. Many of these phenotypes are discrete and...
6.
Wang Z, Petricca J, Liu M, Zhang S, Chen S, Li M, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2220472120.
PMID: 37549269
Dysregulation of histone lysine methyltransferases and demethylases is one of the major mechanisms driving the epigenetic reprogramming of transcriptional networks in castration-resistant prostate cancer (CRPC). In addition to their canonical...
7.
Han D, Owiredu J, Healy B, Li M, Labaf M, Steinfeld J, et al.
Cancer Res
. 2021 Feb;
81(14):3766-3776.
PMID: 33632899
Although American men of European ancestry represent the largest population of patients with prostate cancer, men of African ancestry are disproportionately affected by prostate cancer, with higher prevalence and worse...
8.
Siegfried K, Steinfeld J
Methods Mol Biol
. 2021 Feb;
2218:253-263.
PMID: 33606237
Zebrafish is an excellent system for the study of gonad development due to available genetic tools and its utilization as a human disease model. The zebrafish serves as an experimental...
9.
Webster K, Henke K, Ingalls D, Nahrin A, Harris M, Siegfried K
Reproduction
. 2019 Feb;
157(4):383-398.
PMID: 30763280
Germ cell differentiation and maintenance relies on complex regulation of mitotic and meiotic progression. Cyclin-dependent kinases (CDKs) and their activating cyclin partners are known to have specialized roles in regulating...
10.