Keizo Sugasawa
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Explore the profile of Keizo Sugasawa including associated specialties, affiliations and a list of published articles.
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9
Citations
98
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Recent Articles
1.
Nadaradjane C, Huang Yang C, Rodriguez-Gabin A, Ye K, Sugasawa K, Atasoylu O, et al.
J Nat Prod
. 2018 Mar;
81(3):607-615.
PMID: 29522336
(+)-Discodermolide is a microtubule-stabilizing agent with potential for the treatment of taxol-refractory malignancies. (+)-Discodermolide congeners containing the C-3'-phenyl side chain of taxol (paclitaxel) were synthesized based on computational docking models...
2.
Ishihara T, Koga Y, Mori K, Sugasawa K, Iwatsuki Y, Hirayama F
Bioorg Med Chem
. 2014 Dec;
22(22):6324-32.
PMID: 25438755
The blood coagulation cascade represents an attractive target for antithrombotic drug development, and recent studies have attempted to identify oral anticoagulants with inhibitory activity for enzymes in this cascade, with...
3.
Emerson D, Weiser B, Psonis J, Liao Z, Taratula O, Fiamengo A, et al.
J Am Chem Soc
. 2013 Mar;
135(14):5389-98.
PMID: 23484901
Recently, we identified 1-aminoanthracene as a fluorescent general anesthetic. To investigate the mechanism of action, a photoactive analogue, 1-azidoanthracene, was synthesized. Administration of 1-azidoanthracene to albino stage 40-47 tadpoles was...
4.
Hirayama F, Koshio H, Ishihara T, Hachiya S, Sugasawa K, Koga Y, et al.
J Med Chem
. 2011 Oct;
54(23):8051-65.
PMID: 21995444
Inhibitors of factor Xa (FXa), a crucial serine protease in the coagulation cascade, have attracted a great deal of attention as a target for developing antithrombotic agents. We previously reported...
5.
Smith A, Sugasawa K, Atasoylu O, Huang Yang C, Horwitz S
J Med Chem
. 2011 Aug;
54(18):6319-27.
PMID: 21870795
Potential binding modes of (+)-discodermolide at the paclitaxel binding site of tubulin have been identified by computational studies based on earlier structural and SAR data. Examination of the prospective binding...
6.
Abe M, Suzuki K, Sakata C, Sugasawa K, Hirayama F, Koga Y, et al.
Eur J Pharmacol
. 2010 Oct;
650(1):58-63.
PMID: 20950606
Eltrombopag, an orally-active small molecule thrombopoietin (TPO) receptor agonist, was used for the first time in 2008 to treat patients with chronic idiopathic thrombocytopenic purpura. Here, we investigated the pharmacological...
7.
Fukushima-Shintani M, Suzuki K, Iwatsuki Y, Abe M, Sugasawa K, Hirayama F, et al.
Eur J Haematol
. 2009 Feb;
82(4):247-54.
PMID: 19183407
Thrombopoietin (TPO) is the principal physiologic regulator of platelet production. We have searched for small molecule compounds that mimic the action of TPO by using human TPO receptor-expressed in Ba/F3...
8.
Fukushima-Shintani M, Suzuki K, Iwatsuki Y, Abe M, Sugasawa K, Hirayama F, et al.
Exp Hematol
. 2008 Jul;
36(10):1337-42.
PMID: 18619724
Objective: AKR-501 (YM477) is an orally active thrombopoietin (TPO) receptor agonist that mimics the biological effect of TPO in vitro and in vivo. Here, we report that AKR-501 in combination...
9.
Shimada I, Maeno K, Kondoh Y, Kaku H, Sugasawa K, Kimura Y, et al.
Bioorg Med Chem
. 2007 Dec;
16(6):3309-20.
PMID: 18083579
To identify potent and selective 5-HT(2C) receptor agonists, a series of novel benzazepine derivatives were synthesized, and their structure-activity relationships examined. The compounds were evaluated for their 5-HT(2C), 5-HT(2A), and...