Onur Atasoylu
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Explore the profile of Onur Atasoylu including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
299
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Recent Articles
1.
Nguyen M, Ye H, Xu Y, Truong L, Horsey A, Zhao P, et al.
ACS Med Chem Lett
. 2023 Mar;
14(3):312-318.
PMID: 36923909
Fibroblast growth factor receptors (FGFRs) are transmembrane receptor tyrosine kinases that regulate multiple physiological processes. Aberrant activation of FGFR2 and FGFR3 has been linked to the pathogenesis of many tumor...
2.
Sokolsky A, Vechorkin O, Hummel J, Styduhar E, Wang A, Nguyen M, et al.
ACS Med Chem Lett
. 2023 Jan;
14(1):116-122.
PMID: 36655134
Herein we report the discovery of a novel biaryl amide series as selective inhibitors of hematopoietic protein kinase 1 (HPK1). Structure-activity relationship development, aided by molecular modeling, identified indazole as...
3.
Ye Q, Liu K, Ye H, Pan J, Sokolsky A, Wang A, et al.
ACS Med Chem Lett
. 2023 Jan;
14(1):5-10.
PMID: 36655125
In spite of the great success of immune checkpoint inhibitors in immune-oncology therapy, an urgent need still exists to identify alternative approaches to broaden the scope of therapeutic coverage. Hematopoietic...
4.
Nguyen M, Atasoylu O, Wu L, Kapilashrami K, Pusey M, Gallagher K, et al.
ACS Med Chem Lett
. 2022 Jul;
13(7):1159-1164.
PMID: 35859885
Activin receptor-like kinase 2 (ALK2) is a transmembrane kinase receptor that mediates the signaling of the members of the TGF-β superfamily. The aberrant activation of ALK2 has been linked to...
5.
Nadaradjane C, Huang Yang C, Rodriguez-Gabin A, Ye K, Sugasawa K, Atasoylu O, et al.
J Nat Prod
. 2018 Mar;
81(3):607-615.
PMID: 29522336
(+)-Discodermolide is a microtubule-stabilizing agent with potential for the treatment of taxol-refractory malignancies. (+)-Discodermolide congeners containing the C-3'-phenyl side chain of taxol (paclitaxel) were synthesized based on computational docking models...
6.
Yeh T, Leissing T, Abboud M, Thinnes C, Atasoylu O, Holt-Martyn J, et al.
Chem Sci
. 2018 Feb;
8(11):7651-7668.
PMID: 29435217
Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1-3) causes upregulation of HIF, thus promoting erythropoiesis and is therefore of therapeutic interest. We describe...
7.
Chan M, Atasoylu O, Hodson E, Tumber A, Leung I, Chowdhury R, et al.
PLoS One
. 2015 Jul;
10(7):e0132004.
PMID: 26147748
As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the hypoxia-inducible transcription factors...
8.
Smith A, Sugasawa K, Atasoylu O, Huang Yang C, Horwitz S
J Med Chem
. 2011 Aug;
54(18):6319-27.
PMID: 21870795
Potential binding modes of (+)-discodermolide at the paclitaxel binding site of tubulin have been identified by computational studies based on earlier structural and SAR data. Examination of the prospective binding...
9.
Xu Q, Huang K, TenDyke K, Marsh J, Liu J, Qiu D, et al.
Anticancer Res
. 2011 Aug;
31(9):2773-9.
PMID: 21868519
The marine natural product (+)-spongistatin 1 is an extremely potent growth inhibitory agent having activity against a wide variety of cancer cell lines, while exhibiting low cytotoxicity against quiescent human...
10.
Ballatore C, Soper J, Piscitelli F, James M, Huang L, Atasoylu O, et al.
J Med Chem
. 2011 Aug;
54(19):6969-83.
PMID: 21863799
Cyclopentane-1,3-diones are known to exhibit pK(a) values typically in the range of carboxylic acids. To explore the potential of the cyclopentane-1,3-dione unit as a carboxylic acid isostere, the physical-chemical properties...